APBB1IP

Gene Symbol	APBB1IP
Entrez Gene	54518
Alt Symbol	INAG1, PREL1, RARP1, RIAM
Species	Human
Gene Type	protein-coding
Description	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
Other Description	APBB1-interacting protein 1|PREL-1|RARP-1|Rap1-GTP-interacting adaptor molecule|Rap1-interacting adaptor molecule|amyloid beta A4 precursor protein-binding family B member 1-interacting protein|proline rich EVH1 ligand 1|proline-rich EVH1 ligand 1|proline-rich protein 73|rap1-GTP-interacting adapter molecule|retinoic acid-responsive proline-rich protein 1
Swissprots	Q8IYL7 Q8IZZ7 Q8IWS8 Q7Z5R6
Accessions	CCQ43613 EAW86095 EAW86096 EAW86097 EAW86098 EAW86099 Q7Z5R6 AB085852 BAC41256 AK000812 BAA91384 AK303597 BAG64612 AK308916 AY152730 AAN75525 BC035636 AAH35636 BC054516 AAH54516 BM150270 BM556115 XM_006717451 XP_006717514 XM_011519514 XP_011517816 NM_019043 NP_061916
Function	Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin- induced promoter activities through AP1 and SRE. Mediates Rap1- induced adhesion. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}.
Subcellular Location	Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F- actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity). {ECO:0000250}.
Tissue Specificity	Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}.
Top Pathways	Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RIAM full length protein - ab162767 from Abcam Category Protein Source Wheat germ Species Human

Human RIAM full length protein - ab162768 from Abcam Category Protein Source Wheat germ Species Human

APBB1IP / RIAM Antibody Blocking Peptide - LS-E20921 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APBB1IP / RIAM Antibody Blocking Peptide - LS-E20922 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RIAM/APBB1IP Protein - H00054518-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human RIAM/APBB1IP Protein - H00054518-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

APBB1IP-Antibody-Center-Blocking-Peptide - BP6977c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

APBB1IP Blocking Peptide - 33R-5496 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Apbb1ip Blocking Peptide - 33R-8076 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

APBB1IP - H00054518-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

APBB1IP - H00054518-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

APBB1IP - H00054518-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

APBB1IP - H00054518-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

APBB1IP - H00054518-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RIAM,APBB1IP fusion protein - ag4602 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

RIAM,APBB1IP fusion protein - Ag4327 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Amyloid Beta Precursor Protein Binding B1 Interacting Protein (APBB1IP) - RPM488Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Amyloid Beta Precursor Protein Binding B1 Interacting Protein (APBB1IP) - RPM488Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Amyloid beta A4 precursor protein-binding family B member 1-interacting protein(APBB1IP) - CSB-YP773797HU CSB-EP773797HU CSB-BP773797HU CSB-MP773797HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

APBB1IP Protein - abx163143 from Abbexa Category Protein Species Human

APBB1IP - TP308712 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP) , Recombinant Protein - MBS1421751 from MyBioSource Category Protein Prices $2,500.00, $2,500.00, $2,920.00, $2,920.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

RIAM/APBB1IP Protein - NBP2-14300PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

RIAM/APBB1IP Recombinant Protein Antigen - NBP2-39009PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

APBB1IP Peptide, Human - M34GP00742H from Creative Peptides Category Peptide Source Synthetic. Species Human

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