APBB1IP

Gene Symbol APBB1IP
Entrez Gene 54518
Alt Symbol INAG1, PREL1, RARP1, RIAM
Species Human
Gene Type protein-coding
Description amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
Other Description APBB1-interacting protein 1|PREL-1|RARP-1|Rap1-GTP-interacting adaptor molecule|Rap1-interacting adaptor molecule|amyloid beta A4 precursor protein-binding family B member 1-interacting protein|proline rich EVH1 ligand 1|proline-rich EVH1 ligand 1|proline-rich protein 73|rap1-GTP-interacting adapter molecule|retinoic acid-responsive proline-rich protein 1
Swissprots Q8IYL7 Q8IZZ7 Q8IWS8 Q7Z5R6
Accessions CCQ43613 EAW86095 EAW86096 EAW86097 EAW86098 EAW86099 Q7Z5R6 AB085852 BAC41256 AK000812 BAA91384 AK303597 BAG64612 AK308916 AY152730 AAN75525 BC035636 AAH35636 BC054516 AAH54516 BM150270 BM556115 XM_006717451 XP_006717514 XM_011519514 XP_011517816 NM_019043 NP_061916
Function Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin- induced promoter activities through AP1 and SRE. Mediates Rap1- induced adhesion. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}.
Subcellular Location Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F- actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity). {ECO:0000250}.
Tissue Specificity Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}.
Top Pathways Rap1 signaling pathway

APBB1IP (N-13) - sc-104813 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-RIAM antibody [7E7A3] - N-terminal - ab201991 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 7E7A3
Anti-RIAM antibody [7E7A3] - N-terminal (ab201991) at 1/500 dilution + Human RIAM (aa1-151) recombinant protein

Anti-RIAM antibody [7E7D12] - N-terminal - ab201970 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 7E7D12
Immunohistochemical analysis of paraffin-embedded lymph tissues labeling RIAM using ab201970 at 1/200 with DAB staining.

Anti-RIAM antibody [EPR2805Y] - ab76090 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2805Y
Immunohistochemical analysis of paraffin-embedded human tonsils, using ab76090, at 1/100 dilution.

Anti-RIAM antibody [EPR2806] - ab92537 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2806
All lanes : Anti-RIAM antibody [EPR2806] (ab92537) at 1/2000 dilutionLane 1 : Human Lymph node lysateLane 2 : Fetal brain lysateLane 3 : Human spleen lysateLane 4 : Jurkat cell lysateLane 5 : HL-60 + retinoic acid cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-APBB1IP / RIAM Antibody (aa38-87) - LS-C135440 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
APBB1IP / RIAM antibody LS-C135440 Western blot of Rat Liver lysate.

Anti-APBB1IP / RIAM Antibody (aa71-120) - LS-C112027 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
APBB1IP / RIAM antibody LS-C112027 Western blot of 721_B cell lysate.

Anti-APBB1IP / RIAM Antibody (N-Terminus, clone EPR2805Y) - LS-C105415 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2805Y
IHC of paraffin-embedded human tonsils using anti-RIAM antibody (LS-C105415).

Anti-APBB1IP / RIAM Antibody (Internal, clone EP2806) - LS-C105637 from LifeSpan Bioscience

Prices $450.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2806
IHC of paraffin-embedded human tonsil tissue using anti-RIAM antibody.

Anti-APBB1IP / RIAM Antibody (aa647-666) - LS-C313493 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
APBB1IP / RIAM antibody. ICC: JURKAT Cell.

RIAM/APBB1IP Antibody (EP2806) - NBP1-40722 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP2806
Western Blot: RIAM/APBB1IP Antibody (EP2806) [NBP1-40722] - (A) Human Lymph node (B) Fetal brain © Human spleen (D) Jurkat and (E) HL-60 + retinoic acid cell lysates.

RIAM/APBB1IP Antibody - AF7279 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of THP‑1 human acute monocytic leukemia cell line and EL‑4 mouse lymphoblast cell line. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human RIAM/APBB1IP Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7279) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for RIAM/APBB1IP at approximately 100-110 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

RIAM/APBB1IP Antibody - NBP1-91631 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

RIAM/APBB1IP Antibody - NBP2-39009 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: RIAM/APBB1IP Antibody [NBP2-39009] - Staining of human tonsil shows strong cytoplasmic positivity in germinal and non germinal center cells.

RIAM/APBB1IP Antibody - NBP2-14300 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: RIAM/APBB1IP Antibody [NBP2-14300] - Staining of human appendix shows strong cytoplasmic positivity in lymphoid tissues. Epithelial cells in glands are unstained.

APBB1 interacting protein 1 Antibody - bs-6172R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit

Anti-APBB1IP, (N-terminal) antibody produced in rabbit - SAB2106092 from Sigma-Aldrich

Prices $347.50, $347.50
Sizes 50 µg, 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-APBB1IP (N-Terminal): <B>Cat. No. SAB2106092</B>: APBB1IP in 721_B cell lysates with APBB1IP antibody at 1.0 μg/mL.

Anti-APBB1IP antibody produced in rabbit - HPA017009 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-APBB1IP:<B>Cat. No. HPA017009</B>: Immunohistochemical staining of human appendix shows strong cytoplasmic positivity in lymphoid tissues. Epithelial cells in glands are unstained.

APBB1IP antibody - N-terminal region (ARP57312_P050) - ARP57312_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RIAM-Antibody - AJ1689a from Abgent, a WuXi AppTec company

Host Rabbit
Clonality Monoclonal
Clone EPR2805Y
A. Western blot analysis on (A) HL-60 + Retinoic acid (B) HL-60 cell lysates and (C) Human thymus lysate using anti-RIAM RabMAb (Cat. #AJ1689a), dilution 1:2000.

RIAM-Antibody - AJ1689b from Abgent, a WuXi AppTec company

Host Rabbit
Clonality Monoclonal
Clone EPR2806
Western blot analysis on (A) Human Lymph node (B) Fetal brain (C) human spleen (D) Jurkat and (E) HL-60 + retinoic acid cell lysates using anti-RIAM RabMAb (Cat. #AJ1689b).

APBB1IP antibody [N2C1], Internal - GTX120027 from GeneTex

Host Rabbit
Clonality Polyclonal

Anti -APBB1IP (APBB1-interacting protein 1, Proline-rich EVH1 ligand 1) - 144173 from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Human/Mouse RIAM/APBB1IP Antibody - AF7279 from R&D Systems

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Detection of Human and Mouse RIAM/APBB1IP by Western Blot. Western blot shows lysates of THP-1 human acute monocytic leukemia cell line and EL-4 mouse lymphoblast cell line. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human RIAM/APBB1IP Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7279) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016 ). A specific band was detected for RIAM/APBB1IP at approximately 100-110 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8 .
Detection of Human and Mouse RIAM/APBB1IP by Western Blot. Western blot shows lysates of THP‑1 human acute monocytic leukemia cell line and EL‑4 mouse lymphoblast cell line. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human RIAM/APBB1IP Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7279) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for RIAM/APBB1IP at approximately 100-110 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.
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