| Gene Symbol |
IZUMO1R
|
| Entrez Gene |
390243
|
| Alt Symbol |
FOLR4, Folbp3, JUNO
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
IZUMO1 receptor, JUNO
|
| Other Description |
FR-delta|IZUMO1 receptor protein JUNO|folate receptor 4 (delta) homolog|folate receptor 4, delta (putative)|folate receptor delta|probable folate receptor delta|sperm-egg fusion protein Juno
|
| Swissprots |
A6ND01
|
| Accessions |
A6ND01 XM_011542811 XP_011541113 XM_011542812 XP_011541114 NM_001080486 NM_001199206 NP_001186135
|
| Function |
Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand- receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Note=GPI-anchored at the oolemma. {ECO:0000250}.
|
| Top Pathways |
Endocytosis
|