| Gene Symbol | IZUMO1R |
|---|---|
| Entrez Gene | 390243 |
| Alt Symbol | FOLR4, Folbp3, JUNO |
| Species | Human |
| Gene Type | protein-coding |
| Description | IZUMO1 receptor, JUNO |
| Other Description | FR-delta|IZUMO1 receptor protein JUNO|folate receptor 4 (delta) homolog|folate receptor 4, delta (putative)|folate receptor delta|probable folate receptor delta|sperm-egg fusion protein Juno |
| Swissprots | A6ND01 |
| Accessions | A6ND01 XM_011542811 XP_011541113 XM_011542812 XP_011541114 NM_001080486 NM_001199206 NP_001186135 |
| Function | Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand- receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Note=GPI-anchored at the oolemma. {ECO:0000250}. |
| Top Pathways | Endocytosis |
δ-FR siRNA (h) - sc-39973 from Santa Cruz Biotechnology
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δ-FR shRNA Plasmid (h) - sc-39973-SH from Santa Cruz Biotechnology
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δ-FR shRNA (h) Lentiviral Particles - sc-39973-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN8870 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8870 from Sigma-Aldrich
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FOLR4 siRNA (Human) - CRJ7964 from Cohesion Biosciences
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FOLR4 - MBS8203022 from MyBioSource
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FOLR4 shRNA Plasmid (Human) - CHJ7964 from Cohesion Biosciences
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