| Gene Symbol |
GFI1
|
| Entrez Gene |
2672
|
| Alt Symbol |
GFI-1, GFI1A, SCN2, ZNF163
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
growth factor independent 1 transcription repressor
|
| Other Description |
growth factor independence-1|growth factor independent protein 1|zinc finger protein 163|zinc finger protein Gfi-1
|
| Swissprots |
Q99684 Q8N564
|
| Accessions |
CDL93503 EAW73092 EAW73093 EAW73094 Q99684 AB209606 BAD92843 AK123009 BAG53846 AK313876 BC032751 AAH32751 BC074866 AAH74866 BC074867 AAH74867 BE242676 BM150826 BQ336135 DA927584 DB129173 DB137690 DQ891273 ABM82199 DQ894461 ABM85387 U67369 AAB37272 XM_005270749 XP_005270806 XM_011541245 XP_011539547 XM_011541246 XP_011539548 NM_001127215 NP_001120687 NM_001127216 NP_001120688 NM_005263 NP_005254
|
| Function |
Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2- GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin- mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1- dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB p
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11060035, ECO:0000269|PubMed:12874834, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:8754800}. Note=Colocalizes with PIAS3 and RUNX1T1 in nuclear dots.
|