GFI1

Gene Symbol	GFI1
Entrez Gene	2672
Alt Symbol	GFI-1, GFI1A, SCN2, ZNF163
Species	Human
Gene Type	protein-coding
Description	growth factor independent 1 transcription repressor
Other Description	growth factor independence-1|growth factor independent protein 1|zinc finger protein 163|zinc finger protein Gfi-1
Swissprots	Q99684 Q8N564
Accessions	CDL93503 EAW73092 EAW73093 EAW73094 Q99684 AB209606 BAD92843 AK123009 BAG53846 AK313876 BC032751 AAH32751 BC074866 AAH74866 BC074867 AAH74867 BE242676 BM150826 BQ336135 DA927584 DB129173 DB137690 DQ891273 ABM82199 DQ894461 ABM85387 U67369 AAB37272 XM_005270749 XP_005270806 XM_011541245 XP_011539547 XM_011541246 XP_011539548 NM_001127215 NP_001120687 NM_001127216 NP_001120688 NM_005263 NP_005254
Function	Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2- GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin- mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1- dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB p
Subcellular Location	Nucleus {ECO:0000269|PubMed:11060035, ECO:0000269|PubMed:12874834, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:8754800}. Note=Colocalizes with PIAS3 and RUNX1T1 in nuclear dots.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GFI1 peptide - ab22461 from Abcam Category Peptide

Human GFI1 protein fragment - ab152422 from Abcam Category Protein Source Wheat germ Species Human

GFI1 Antibody Blocking Peptide - LS-E11426 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human GFI-1 Protein - H00002672-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ZNF163 - H00002672-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ZNF163 - H00002672-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

GFI1 fusion protein - Ag5401 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human GFI1, His-tagged - GFI1-13229H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Zinc finger protein Gfi-1(GFI1) - CSB-YP858722HU CSB-EP858722HU CSB-BP858722HU CSB-MP858722HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ZNF163 (full length, N-term HIS tag, transcript variant 1) - TP760157 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

ZNF163 (N-term HIS tag, transcript variant 2) - TP760646 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

ZNF163 (full length, N-term HIS tag, transcript variant 3) - TP760818 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

Zinc finger protein Gfi-1 (GFI1) , Recombinant Protein - MBS1314619 from MyBioSource Category Protein Prices $1,930.00, $1,930.00, $2,395.00, $2,395.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human GFI1 protein, GST-tagged - GFI1-188H from Creative Biomart Category Protein Source Wheat Germ Species Human

Recombinant Human GFI1 protein, His-tagged - GFI1-185H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human GFI1 protein, His-tagged - GFI1-186H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human GFI1 protein, His-tagged - GFI1-187H from Creative Biomart Category Protein Source E. coli Species Human

GFI1 Peptide, Human - M34GP06214H from Creative Peptides Category Peptide Source Synthetic. Species Human

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