GFI1

Gene Symbol	GFI1
Entrez Gene	2672
Alt Symbol	GFI-1, GFI1A, SCN2, ZNF163
Species	Human
Gene Type	protein-coding
Description	growth factor independent 1 transcription repressor
Other Description	growth factor independence-1|growth factor independent protein 1|zinc finger protein 163|zinc finger protein Gfi-1
Swissprots	Q99684 Q8N564
Accessions	CDL93503 EAW73092 EAW73093 EAW73094 Q99684 AB209606 BAD92843 AK123009 BAG53846 AK313876 BC032751 AAH32751 BC074866 AAH74866 BC074867 AAH74867 BE242676 BM150826 BQ336135 DA927584 DB129173 DB137690 DQ891273 ABM82199 DQ894461 ABM85387 U67369 AAB37272 XM_005270749 XP_005270806 XM_011541245 XP_011539547 XM_011541246 XP_011539548 NM_001127215 NP_001120687 NM_001127216 NP_001120688 NM_005263 NP_005254
Function	Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2- GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin- mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1- dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB p
Subcellular Location	Nucleus {ECO:0000269|PubMed:11060035, ECO:0000269|PubMed:12874834, ECO:0000269|PubMed:18805794, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:8754800}. Note=Colocalizes with PIAS3 and RUNX1T1 in nuclear dots.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GFI1 HEK293 Cell Transient Overexpression Lysate (Non-Denatured) - L098T6 from Acris Antibodies Category Cell Lysate Prices $290.00 Sizes 100 µg

GFI1 293 Cell Lysate - 408147 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

GFI-1 Overexpression Lysate (Native) - NBL1-11045 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Gfi-1 (h): 293T Lysate - sc-115318 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Gfi-1 (h3): 293T Lysate - sc-159136 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

GFI1 Over-expression Lysate Product - GWB-6E0AFC from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

GFI-1 Overexpression Lysate (Native) - NBP2-09431 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

GFI-1 Overexpression Lysate (Native) - NBP2-09430 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human GFI1 Knockdown Stable Cell Line - CSC-DC006214 from Creative biogene Category Cell Line Species Human

Human GFI1 Knockout Cell Line-HEK293T - CSC-RT0659 from Creative biogene Category Cell Line Species Human

GFI1 KO Cell Lysate-HEK293T - CLKO-0165 from Creative biogene Category Cell Lysate

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