| Gene Symbol |
RAB7A
|
| Entrez Gene |
7879
|
| Alt Symbol |
PRO2706, RAB7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAB7A, member RAS oncogene family
|
| Other Description |
RAB7, member RAS oncogene family|Ras-associated protein RAB7|ras-related protein Rab-7a
|
| Swissprots |
Q9NWJ0 Q9UPB0 A8K3V6 P51149
|
| Accessions |
AAD02565 CAF33077 EAW79302 P51149 AF119891 AAF69645 AF498942 AAM21090 AK026136 AK094449 AK225177 AK225691 AK290721 BAF83410 AK298344 BAG60591 AK308934 AL162009 AU122058 BC008721 AAH08721 BC013728 AAH13728 BC014200 BX537775 CAD97836 CA748697 U44104 AAA86640 NM_004637 NP_004628
|
| Function |
Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the
|
| Subcellular Location |
Late endosome. Lysosome {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Melanosome {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane; Lipid- anchor; Cytoplasmic side. Note=Colocalizes with OSBPL1A at the late endosome. Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Recruited to phagosomes containing S.aureus or Mycobacterium (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed; high expression found in skeletal muscle. {ECO:0000269|PubMed:12545426}.
|
| Top Pathways |
Endocytosis, Phagosome, Amoebiasis, Salmonella infection, Tuberculosis
|
![Western Blot: RAB7A Overexpression Lysate (Adult Normal) [NBL1-15087] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RAB7A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6630_RAB7A%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15087-img0002.jpg)