RAB7A

Gene Symbol	RAB7A
Entrez Gene	7879
Alt Symbol	PRO2706, RAB7
Species	Human
Gene Type	protein-coding
Description	RAB7A, member RAS oncogene family
Other Description	RAB7, member RAS oncogene family|Ras-associated protein RAB7|ras-related protein Rab-7a
Swissprots	Q9NWJ0 Q9UPB0 A8K3V6 P51149
Accessions	AAD02565 CAF33077 EAW79302 P51149 AF119891 AAF69645 AF498942 AAM21090 AK026136 AK094449 AK225177 AK225691 AK290721 BAF83410 AK298344 BAG60591 AK308934 AL162009 AU122058 BC008721 AAH08721 BC013728 AAH13728 BC014200 BX537775 CAD97836 CA748697 U44104 AAA86640 NM_004637 NP_004628
Function	Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the
Subcellular Location	Late endosome. Lysosome {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Melanosome {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane; Lipid- anchor; Cytoplasmic side. Note=Colocalizes with OSBPL1A at the late endosome. Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Recruited to phagosomes containing S.aureus or Mycobacterium (By similarity). {ECO:0000250}.
Tissue Specificity	Widely expressed; high expression found in skeletal muscle. {ECO:0000269|PubMed:12545426}.
Top Pathways	Endocytosis, Phagosome, Amoebiasis, Salmonella infection, Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active dog RAB7 full length protein - ab89986 from Abcam Category Protein Prices $302.00 Sizes 50 µg Source E. coli Species Dog

Human RAB7 (mutated Q67 L) full length protein - ab176677 from Abcam Category Protein Source E. coli Species Human

Human RAB7 full length protein - ab103507 from Abcam Category Protein Source E. coli Species Human

Human RAB7 full length protein - ab176668 from Abcam Category Protein Source E. coli Species Human

RAB7A / RAB7 Antibody Blocking Peptide - LS-E9709 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Rab7a Recombinant Protein - H00007879-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Rab7a Protein - NBP1-50961 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E.coli Species Human

RAB7-Antibody-C-term-Blocking-Peptide - BP8665b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RAB7A Protein - GTX109102-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

RAB7A Protein (OPPA00052) - OPPA00052 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source Escherichia Coli.

Human RAB7A protein - orb169154 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

RAB7A / RAB7 (1-207, His-tag) - AR09817PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

RAB7A / RAB7 (1-207, His-tag) - AR09817PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

RAB7A / RAB7 - H00007879-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RAB7A / RAB7 - H00007879-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RAB7A, Member RAS Oncogene Family, Human Recombinant - 228-12797-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human RAB7A, Member RAS Oncogene Family - 228-12797-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human RAB7A, Member RAS Oncogene Family - 228-12797-3 from RayBiotech Category Protein Prices $2,880.00 Sizes 3 µg Source Escherichia Coli. Species Human

RAB7A, 1-207aa, Human, His tag, E.coli - 01-RAB7A from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

RAB7A fusion protein - ag19666 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

RAB7A fusion protein - ag6319 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human RAB7A, Member RAS Oncogene Family Protein - BP002354-PRO-077 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

RAB7A, 1-207aa, Recombinant Protein - GWB-P1161D from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

RAB7A Human Protein - GWB-BSP590 from Genway Biotech Category Protein Prices $75.00, $165.00, $3,230.00 Sizes 5 μg, 20 μg, 1000 μg Source Escherichia Coli. Species Human

Recombinant Human RAB6B, His-tagged - RAB6B-3413H from Creative Biomart Category Protein

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