RAB7A

Gene Symbol RAB7A
Entrez Gene 7879
Alt Symbol PRO2706, RAB7
Species Human
Gene Type protein-coding
Description RAB7A, member RAS oncogene family
Other Description RAB7, member RAS oncogene family|Ras-associated protein RAB7|ras-related protein Rab-7a
Swissprots Q9NWJ0 Q9UPB0 A8K3V6 P51149
Accessions AAD02565 CAF33077 EAW79302 P51149 AF119891 AAF69645 AF498942 AAM21090 AK026136 AK094449 AK225177 AK225691 AK290721 BAF83410 AK298344 BAG60591 AK308934 AL162009 AU122058 BC008721 AAH08721 BC013728 AAH13728 BC014200 BX537775 CAD97836 CA748697 U44104 AAA86640 NM_004637 NP_004628
Function Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the
Subcellular Location Late endosome. Lysosome {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Melanosome {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane; Lipid- anchor; Cytoplasmic side. Note=Colocalizes with OSBPL1A at the late endosome. Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Recruited to phagosomes containing S.aureus or Mycobacterium (By similarity). {ECO:0000250}.
Tissue Specificity Widely expressed; high expression found in skeletal muscle. {ECO:0000269|PubMed:12545426}.
Top Pathways Endocytosis, Phagosome, Amoebiasis, Salmonella infection, Tuberculosis

Rab7 (D95F2) XP ® Rabbit mAb (HRP Conjugate) - 12561 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D95F2
Western blot analysis of extracts from COS-7 and HeLa cells using Rab7 (D95F2) XP ® Rabbit mAb (HRP Conjugate).

Rab7 (D95F2) XP ® Rabbit mAb - 9367 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D95F2
Western blot analysis of extracts from various cell lines using Rab7 (D95F2) XP ® Rabbit mAb.

Rab7 Antibody - 2094 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from SK-MEL-28 and NIH/3T3 cells using Rab7 Antibody.

Rab 7 (C-19) - sc-6563 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Rab 7 (C-19): sc-6563. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic localization.

Rab 7 (A-16) - sc-11303 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Rab 7 (D-4) - sc-271608 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Rab 7 (D-4): sc-271608. Western blot analysis of Rab 7 expression in non-transfected: sc-117752 (A) and mouse Rab 7 transfected: sc-122913 (B) 293T whole cell lysates.

Rab 7 (H-50) - sc-10767 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Rab 7 (H-50): sc-10767. Immunofluorescence staining of normal mouse intestine frozen section showing cytoplasmic staining.

Anti-RAB7 antibody - ab187868 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RAB7 antibody (ab187868) at 1/1000 dilutionLane 1 : L6 (Rat skeletal muscle cell line) cell lysateLane 2 : L-929 (Mouse connective tissue fibroblast cells) cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-RAB7 antibody - ab74906 from Abcam

Host Rabbit
Clonality Polyclonal
ab74906 (2µg/ml) staining Rab 7 in human stomach using an automated system (DAKO Autostainer Plus). Using this protocol there is cytoplasmic staining of gastric mucosa.Sections were rehydrated and antigen retrieved with the Dako 3 in 1 AR buffer EDTA pH 9.0 in a DAKO PT link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 mins. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 min and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with Diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that, for manual staining, optimization of primary antibody concentration and incubation time is recommended. Signal amplification may be required.

Anti-RAB7 antibody - ab55890 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RAB7 antibody [EPR7588(B)] - Late Endosome Marker - ab126712 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7588(B)
ab126712, at 1/50, staining Rab7A in Paraffin-embedded Human colon adenocarcinoma tissue by Immunohistochemistry.

Anti-RAB7 antibody [EPR7589] - ab137029 from Abcam

Prices $397.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7589
ab137029 staining RAB7 in Human HepaRG cell by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with formaldehyde, permeabilized with 0.1% Triton X-100 in PBS and blocked with 1% milk for 30 minutes at room temperature. Samples were incubated with primary antibody (1/200 in 1% milk) for 30 minutes. An Alexa Fluor®488-conjugated Donkey anti-rabbit IgG polyclonal (1/400) was used as the secondary antibody.See Abreview

Anti-RAB7 antibody [EPR7589] (Alexa Fluor® 647) - ab198337 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7589
ab198337 staining RAB7 in A375 cells. The cells were fixed with 4% formaldehyde (10 min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab198337 at 1/100 dilution (shown in red) and ab195887, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 488), at 1/250 dilution (shown in green). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).This product also gave a positive signal under the same testing conditions in A375 cells fixed with 100% methanol (5min).

Anti-RAB7 antibody - C-terminal - ab135706 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-RAB7 antibody - C-terminal (ab135706) at 1/100 dilution + K562 cell lysate at 35 µg

Anti-RAB7A / RAB7 Antibody (C-Terminus) - LS-C47103 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RAB7A / RAB7 Antibody (Asp193) - LS-C75301 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RAB7A / RAB7 Antibody (C-Terminus, APC) - LS-C220496 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RAB7A / RAB7 Antibody (C-Terminus, AP) - LS-C220497 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RAB7A / RAB7 Antibody (C-Terminus, Biotin) - LS-C220498 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RAB7A / RAB7 Antibody (C-Terminus, FITC) - LS-C220499 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RAB7A / RAB7 Antibody (C-Terminus, Azide-free, HRP) - LS-C220501 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RAB7A / RAB7 Antibody (C-Terminus, PE) - LS-C220502 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RAB7A / RAB7 Antibody (C-Terminus) - LS-C330620 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RAB7A / RAB7 Antibody - LS-C192407 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of RAB7A pAb in extracts from K562 cells.

Anti-RAB7A / RAB7 Antibody - LS-C83876 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of RAB7 in NIH/3T3 cell lysates.
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