| Gene Symbol | RAB7A |
|---|---|
| Entrez Gene | 7879 |
| Alt Symbol | PRO2706, RAB7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | RAB7A, member RAS oncogene family |
| Other Description | RAB7, member RAS oncogene family|Ras-associated protein RAB7|ras-related protein Rab-7a |
| Swissprots | Q9NWJ0 Q9UPB0 A8K3V6 P51149 |
| Accessions | AAD02565 CAF33077 EAW79302 P51149 AF119891 AAF69645 AF498942 AAM21090 AK026136 AK094449 AK225177 AK225691 AK290721 BAF83410 AK298344 BAG60591 AK308934 AL162009 AU122058 BC008721 AAH08721 BC013728 AAH13728 BC014200 BX537775 CAD97836 CA748697 U44104 AAA86640 NM_004637 NP_004628 |
| Function | Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient- transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the |
| Subcellular Location | Late endosome. Lysosome {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Melanosome {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane; Lipid- anchor; Cytoplasmic side. Note=Colocalizes with OSBPL1A at the late endosome. Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Recruited to phagosomes containing S.aureus or Mycobacterium (By similarity). {ECO:0000250}. |
| Tissue Specificity | Widely expressed; high expression found in skeletal muscle. {ECO:0000269|PubMed:12545426}. |
| Top Pathways | Endocytosis, Phagosome, Amoebiasis, Salmonella infection, Tuberculosis |
Rab 7 CRISPR/Cas9 KO Plasmid (h) - sc-400465 from Santa Cruz Biotechnology
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Rab 7 HDR Plasmid (h) - sc-400465-HDR from Santa Cruz Biotechnology
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Rab 7 Double Nickase Plasmid (h) - sc-400465-NIC from Santa Cruz Biotechnology
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Rab 7 Double Nickase Plasmid (h2) - sc-400465-NIC-2 from Santa Cruz Biotechnology
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Rab 7 CRISPR Activation Plasmid (h) - sc-400465-ACT from Santa Cruz Biotechnology
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Rab 7 CRISPR Activation Plasmid (h2) - sc-400465-ACT-2 from Santa Cruz Biotechnology
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Rab 7 Lentiviral Activation Particles (h) - sc-400465-LAC from Santa Cruz Biotechnology
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Rab 7 Lentiviral Activation Particles (h2) - sc-400465-LAC-2 from Santa Cruz Biotechnology
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Rab 7 siRNA (h) - sc-29460 from Santa Cruz Biotechnology
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Rab 7 shRNA Plasmid (h) - sc-29460-SH from Santa Cruz Biotechnology
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Rab 7 shRNA (h) Lentiviral Particles - sc-29460-V from Santa Cruz Biotechnology
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Rab 7 siRNA (m2) - sc-270071 from Santa Cruz Biotechnology
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Rab 7 shRNA Plasmid (m2) - sc-270071-SH from Santa Cruz Biotechnology
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Rab 7 shRNA (m2) Lentiviral Particles - sc-270071-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU053221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17865 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17865 from Sigma-Aldrich
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RAB7A siRNA (Human) - CRH5306 from Cohesion Biosciences
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Rab7a RNAi - H00007879-R01 from Novus Biologicals
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RAB7A - MBS8221109 from MyBioSource
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shRNA set against Human Rab7 (NM_004637.5) - SHH388560 from Creative biogene
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shRNA set against Human RAB7A(NM_004637.5) - SHR107466 from Creative biogene
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Human RAB7A siRNA - orb265808 from Biorbyt
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RAB7A shRNA Plasmid (Human) - CHH5306 from Cohesion Biosciences
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RAB7A miRNA 3'UTR clone - MiUTR1H-08575 from Creative biogene
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