HRH3

Gene Symbol HRH3
Entrez Gene 11255
Alt Symbol GPCR97, HH3R
Species Human
Gene Type protein-coding
Description histamine receptor H3
Other Description G protein-coupled receptor 97|G-protein coupled receptor 97|H3R|histamine H3 receptor
Swissprots Q9Y5N1 Q9H4K8 Q9GZX2 Q4QRI7
Accessions CAC39434 CAC51025 EAW75381 EAW75382 EAW75383 EAW75384 EAW75385 Q9Y5N1 AB019000 BAB17030 AF140538 AAD38151 AF321910 AAL71911 AF321911 AAL71912 AF321912 AAL71913 AF321913 AAL71914 AF346903 AAM43828 AF346904 AAM43829 AF363791 AAK50040 AK074730 BAC11167 BC096840 AAH96840 XM_005260266 XP_005260323 XM_005260267 XP_005260324 NM_007232 NP_009163
Function The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra.
Top Pathways Neuroactive ligand-receptor interaction

Histamine H3 Receptor (C-20) - sc-17921 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Histamine H3 Receptor (C-20): sc-17921. Western blot analysis of Histamine H3 Receptor expression in C6 (A), A549 (B), CHO-K1 (C), untreated SK-N-MC (D) and forskolin-induced SK-N-MC (E) whole cell lysates.

Histamine H3 Receptor (H-130) - sc-50311 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Histamine H3 Receptor (N-20) - sc-17919 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Histamine H3 Receptor (P-15) - sc-33976 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Histamine H3 Receptor (D-5) - sc-390140 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Histamine H3 Receptor (D-5): sc-390140. Western blot analysis of Histamine H3 Receptor expression in A549 (A), CHO-K1 (B), C6 (C), SK-N-MC (D) and forskolin treated SK-N-MC (E) whole cell lysates.

Anti-HRH3 antibody - ab84468 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-HRH3 antibody (ab84468) at 1/500 dilution + 35µg of Jurkat whole cell lysate

Anti-HRH3 antibody - ab96787 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HRH3 antibody (ab96787) at 1/1000 dilutionLane 1 : A431 whole cell lysateLane 2 : H1299 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-HRH3 antibody - ab56935 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56935 HRH3 antibody at 1ug/ml.

Anti-HRH3 antibody - ab97450 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HRH3 antibody (ab97450) at 1/5000 dilution + HeLa whole cell lysate at 30 µg

Anti-HRH3 antibody [EPR5631] - ab124732 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5631
All lanes : Anti-HRH3 antibody [EPR5631] (ab124732)Lane 1 : Jurkat cell lysateLane 2 : SH-SY5Y cell lysateLane 3 : C6 cell lysateLane 4 : A549 cell lysateLane 5 : Neuro-2a cell lysateLysates/proteins at 10 µg per lane.

Anti-HRH3 antibody - C-terminal - ab135500 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of Formalin-fixed, paraffin-embedded Human brain tissue labelling HRH3 with ab135500 at 1/10 dilution followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-HRH3 / Histamine 3 Receptor Antibody (N-Terminus) - LS-C24237 from LifeSpan Bioscience

Prices $415.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-HRH3 / Histamine 3 Receptor Antibody (N-Terminus) - LS-C24238 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-HRH3 / Histamine 3 Receptor Antibody (C-Terminus) - LS-C24240 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-HRH3 / Histamine 3 Receptor Antibody (C-Terminus) - LS-C24239 from LifeSpan Bioscience

Prices $415.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-HRH3 / Histamine 3 Receptor Antibody (aa315-326) - LS-C112673 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-HRH3 / Histamine 3 Receptor Antibody (aa428-445) - LS-C129771 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HRH3 / Histamine 3 Receptor Antibody (C-Terminus) - LS-C129772 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HRH3 / Histamine 3 Receptor Antibody (C-Terminus, Magnetic beads) - LS-C171947 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HRH3 / Histamine 3 Receptor Antibody (C-Terminus, Sepharose) - LS-C171948 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HRH3 / Histamine 3 Receptor Antibody - LS-C109294 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate). A: A431. B: H1299. 10% SDS PAGE. HRH3 antibody diluted at 1:1000.

Anti-HRH3 / Histamine 3 Receptor Antibody (aa291-340) - LS-C120731 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from COLO205 cells, using HRH3 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-HRH3 / Histamine 3 Receptor Antibody (aa416-445, APC) - LS-C219683 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HRH3 / Histamine 3 Receptor Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A475 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-HRH3 / Histamine H3 Receptor antibody LS-A475 IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-HRH3 / Histamine 3 Receptor Antibody (aa416-445, Biotin) - LS-C219687 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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