| Gene Symbol |
HRH3
|
| Entrez Gene |
11255
|
| Alt Symbol |
GPCR97, HH3R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histamine receptor H3
|
| Other Description |
G protein-coupled receptor 97|G-protein coupled receptor 97|H3R|histamine H3 receptor
|
| Swissprots |
Q9Y5N1 Q9H4K8 Q9GZX2 Q4QRI7
|
| Accessions |
CAC39434 CAC51025 EAW75381 EAW75382 EAW75383 EAW75384 EAW75385 Q9Y5N1 AB019000 BAB17030 AF140538 AAD38151 AF321910 AAL71911 AF321911 AAL71912 AF321912 AAL71913 AF321913 AAL71914 AF346903 AAM43828 AF346904 AAM43829 AF363791 AAK50040 AK074730 BAC11167 BC096840 AAH96840 XM_005260266 XP_005260323 XM_005260267 XP_005260324 NM_007232 NP_009163
|
| Function |
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|