HRH3

Gene Symbol	HRH3
Entrez Gene	11255
Alt Symbol	GPCR97, HH3R
Species	Human
Gene Type	protein-coding
Description	histamine receptor H3
Other Description	G protein-coupled receptor 97|G-protein coupled receptor 97|H3R|histamine H3 receptor
Swissprots	Q9Y5N1 Q9H4K8 Q9GZX2 Q4QRI7
Accessions	CAC39434 CAC51025 EAW75381 EAW75382 EAW75383 EAW75384 EAW75385 Q9Y5N1 AB019000 BAB17030 AF140538 AAD38151 AF321910 AAL71911 AF321911 AAL71912 AF321912 AAL71913 AF321913 AAL71914 AF346903 AAM43828 AF346904 AAM43829 AF363791 AAK50040 AK074730 BAC11167 BC096840 AAH96840 XM_005260266 XP_005260323 XM_005260267 XP_005260324 NM_007232 NP_009163
Function	The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.
Subcellular Location	Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra.
Top Pathways	Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HRH3 protein fragment - ab161380 from Abcam Category Protein Source Wheat germ Species Human

HRH3 / Histamine 3 Receptor Antibody Blocking Peptide - LS-E4648 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HRH3 / Histamine 3 Receptor Antibody Blocking Peptide - LS-E28712 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

HRH3 / Histamine 3 Receptor Antibody Blocking Peptide - LS-E28991 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

HRH3 / Histamine 3 Receptor Antibody Blocking Peptide - LS-E28986 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

HRH3 / Histamine 3 Receptor Antibody Blocking Peptide - LS-E22712 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HRH3 / Histamine 3 Receptor Antibody Blocking Peptide - LS-E22713 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HRH3 / Histamine 3 Receptor Antibody Blocking Peptide - LS-E26989 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HRH3 / Histamine 3 Receptor Antibody Blocking Peptide - LS-E27995 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Histamine H3 R Protein - H00011255-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Histamine H3 R Peptide - P0617 from Novus Biologicals Category Peptide Species Human

HRH3-Antibody-Center-Blocking-Peptide - BP1700c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HRH3-Antibody-C-term-Blocking-Peptide - BP1700b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Histamine H3 Receptor blocking peptide - GTX89494-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Bovine

Histamine H3 Receptor blocking peptide - GTX88224-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

HRH3 Immunizing peptide - orb66462 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

Histamine H3 Receptor Peptide - orb224277 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

HRH3 Peptide - AC21-1813-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

HRH3 Peptide - AC21-2757-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Histamine H3 receptor - H00011255-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Histamine H3 receptor - H00011255-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

HRH3 Peptide - 42-287P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

Recombinant Human HRH3 - HRH3-702H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Histamine Receptor H3 (HRH3) - RPG039Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Histamine H3 Receptor Blocking Peptide - CBP3391 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

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