| Gene Symbol |
EXTL2
|
| Entrez Gene |
2135
|
| Alt Symbol |
EXTR2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
exostosin-like glycosyltransferase 2
|
| Other Description |
EXT-related protein 2|alpha-1,4-N-acetylhexosaminyltransferase EXTL2|alpha-GalNAcT EXTL2|exostoses (multiple)-like 2|exostosin-like 2|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase|processed exostosin-like 2
|
| Swissprots |
D3DT60 B2R795 Q9UBQ6
|
| Accessions |
EAW72946 EAW72947 EAW72948 Q9UBQ6 AB009284 BAA24081 AF000416 AAC02898 AK001450 AK096914 BAC04893 AK298124 BAG60404 AK312895 BAG35742 AU130571 BC014910 AAH14910 BC036015 AAH36015 BC045681 AAH45681 BP202626 BU689972 BX103291 U76189 AAB93669 XM_005270621 XP_005270678 XM_011540994 XP_011539296 XM_011540995 XP_011539297 XM_011540996 XP_011539298 XM_011540997 XP_011539299 XM_011540998 XP_011539300 NM_001033025 NP_001028197 NM_001261440 NP_001248369 NM_001261441 NP_001248370 NM_001261442 NP_001248371 NM_001439 NP_001430 NR_048570
|
| Function |
Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. {ECO:0000269|PubMed:10318803}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
|