| Gene Symbol |
PIGW
|
| Entrez Gene |
284098
|
| Alt Symbol |
Gwt1, HPMRS5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatidylinositol glycan anchor biosynthesis, class W
|
| Other Description |
PIG-W|phosphatidylinositol glycan, class W|phosphatidylinositol-glycan biosynthesis class W protein
|
| Swissprots |
Q7Z7B1 Q8N9G3
|
| Accessions |
EAW57563 EAW57564 Q7Z7B1 AB097818 BAC77021 AK094752 BAC04413 BC054025 BC144220 BC156433 AAI56434 BC160092 AAI60092 BC172479 AAI72479 XM_005257238 XP_005257295 XM_006725318 XP_006725381 XM_011524646 XP_011522948 XM_011546800 XP_011545102 NM_178517 NP_848612
|
| Function |
Required for the transport of GPI-anchored proteins to the plasma membrane (PubMed:24367057). Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (By similarity). {ECO:0000250|UniProtKB:Q7TSN4, ECO:0000269|PubMed:24367057}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q7TSN4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7TSN4}.
|
| Top Pathways |
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
|