Gene Symbol | PIGW |
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Entrez Gene | 284098 |
Alt Symbol | Gwt1, HPMRS5 |
Species | Human |
Gene Type | protein-coding |
Description | phosphatidylinositol glycan anchor biosynthesis, class W |
Other Description | PIG-W|phosphatidylinositol glycan, class W|phosphatidylinositol-glycan biosynthesis class W protein |
Swissprots | Q7Z7B1 Q8N9G3 |
Accessions | EAW57563 EAW57564 Q7Z7B1 AB097818 BAC77021 AK094752 BAC04413 BC054025 BC144220 BC156433 AAI56434 BC160092 AAI60092 BC172479 AAI72479 XM_005257238 XP_005257295 XM_006725318 XP_006725381 XM_011524646 XP_011522948 XM_011546800 XP_011545102 NM_178517 NP_848612 |
Function | Required for the transport of GPI-anchored proteins to the plasma membrane (PubMed:24367057). Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (By similarity). {ECO:0000250|UniProtKB:Q7TSN4, ECO:0000269|PubMed:24367057}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q7TSN4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7TSN4}. |
Top Pathways | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
PIG-W CRISPR/Cas9 KO Plasmid (h) - sc-415354 from Santa Cruz Biotechnology
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PIG-W HDR Plasmid (h) - sc-415354-HDR from Santa Cruz Biotechnology
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PIG-W Double Nickase Plasmid (h) - sc-415354-NIC from Santa Cruz Biotechnology
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PIG-W Double Nickase Plasmid (h2) - sc-415354-NIC-2 from Santa Cruz Biotechnology
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PIG-W CRISPR Activation Plasmid (h) - sc-415354-ACT from Santa Cruz Biotechnology
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PIG-W CRISPR Activation Plasmid (h2) - sc-415354-ACT-2 from Santa Cruz Biotechnology
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PIG-W Lentiviral Activation Particles (h) - sc-415354-LAC from Santa Cruz Biotechnology
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PIG-W Lentiviral Activation Particles (h2) - sc-415354-LAC-2 from Santa Cruz Biotechnology
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PIG-W siRNA (h) - sc-93698 from Santa Cruz Biotechnology
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PIG-W shRNA Plasmid (h) - sc-93698-SH from Santa Cruz Biotechnology
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PIG-W shRNA (h) Lentiviral Particles - sc-93698-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU131341 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16800 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16800 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06093 from Sigma-Aldrich
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PIGW siRNA (Human) - CRJ6969 from Cohesion Biosciences
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shRNA set against Human PIGW (NM_178517.3) - SHH375564 from Creative biogene
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shRNA set against Human PIGW(NM_178517.3) - SHR114558 from Creative biogene
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PIGW shRNA Plasmid (Human) - CHJ6969 from Cohesion Biosciences
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PIGW miRNA 3'UTR clone - MiUTR1H-07898 from Creative biogene
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