| Gene Symbol |
HERC4
|
| Entrez Gene |
26091
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
HECT and RLD domain containing E3 ubiquitin protein ligase 4
|
| Other Description |
HECT domain and RCC1-like domain-containing protein 4|hect domain and RLD 4|probable E3 ubiquitin-protein ligase HERC4
|
| Swissprots |
Q5GC99 Q9HCH9 Q5GC98 Q5GLZ8 Q5GCA0 Q8IXP9
|
| Accessions |
EAW54260 EAW54261 EAW54262 EAW54263 EAW54264 EAW54265 EAW54266 Q5GLZ8 AB046813 BAB13419 AK021844 AK026808 AK027835 AK292809 BAF85498 AL096715 CAB46371 AY221963 AAO65480 AY650032 AAV66578 AY650033 AAV66579 AY650034 AAV66580 BC015043 BC018114 BC039465 BC039600 AAH39600 BX101651 BX537563 DB459623 JF432426 ADZ15643 XM_011539592 XP_011537894 XM_011539593 XP_011537895 XM_011539594 XP_011537896 XM_011539595 XP_011537897 XM_011539596 XP_011537898 XM_011539597 XP_011537899 XM_011539598 XP_011537900 XM_011539599 XP_011537901 NM_001017972 NM_001278185 NP_001265114 NM_001278186 NP_001265115 NM_001278187 NP_001265116 NM_015601 NP_056416 NM_022079 NP_071362
|
| Function |
Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:15676274}. Note=shows a punctate cytoplasmic distribution.
|
| Tissue Specificity |
Expressed in brain and testis and detected in heart and placenta. {ECO:0000269|PubMed:15676274}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|