HERC4

Gene Symbol	HERC4
Entrez Gene	26091
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	HECT and RLD domain containing E3 ubiquitin protein ligase 4
Other Description	HECT domain and RCC1-like domain-containing protein 4|hect domain and RLD 4|probable E3 ubiquitin-protein ligase HERC4
Swissprots	Q5GC99 Q9HCH9 Q5GC98 Q5GLZ8 Q5GCA0 Q8IXP9
Accessions	EAW54260 EAW54261 EAW54262 EAW54263 EAW54264 EAW54265 EAW54266 Q5GLZ8 AB046813 BAB13419 AK021844 AK026808 AK027835 AK292809 BAF85498 AL096715 CAB46371 AY221963 AAO65480 AY650032 AAV66578 AY650033 AAV66579 AY650034 AAV66580 BC015043 BC018114 BC039465 BC039600 AAH39600 BX101651 BX537563 DB459623 JF432426 ADZ15643 XM_011539592 XP_011537894 XM_011539593 XP_011537895 XM_011539594 XP_011537896 XM_011539595 XP_011537897 XM_011539596 XP_011537898 XM_011539597 XP_011537899 XM_011539598 XP_011537900 XM_011539599 XP_011537901 NM_001017972 NM_001278185 NP_001265114 NM_001278186 NP_001265115 NM_001278187 NP_001265116 NM_015601 NP_056416 NM_022079 NP_071362
Function	Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:15676274}. Note=shows a punctate cytoplasmic distribution.
Tissue Specificity	Expressed in brain and testis and detected in heart and placenta. {ECO:0000269|PubMed:15676274}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HERC4 protein fragment - ab167937 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human HERC4 protein fragment - ab127116 from Abcam Category Protein Source E. coli Species Human

HERC4 Antibody Blocking Peptide - LS-E15822 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HERC4 Antibody Blocking Peptide - LS-E15821 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HERC4 Antibody Blocking Peptide - LS-E15929 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human HERC4 Protein - H00026091-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

HERC4 Blocking Peptide - 33R-6183 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HERC4 Blocking Peptide - 33R-9548 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HERC4 Blocking Peptide - 33R-5516 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HERC4 - H00026091-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HERC4 - H00026091-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

HERC4 fusion protein - Ag4566 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

HERC4 fusion protein - Ag5302 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human HERC4, GST-tagged - HERC4-13739H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human HERC4, GST-tagged - HERC4-178H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

HERC4 protein-GST fusion - 009-001-S02 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

HERC4 protein-GST fusion - 009-001-S02S from Rockland Immunochemicals Inc Category Protein Prices $265.00 Sizes 20 µg Species Human

Recombinant Human Probable E3 ubiquitin-protein ligase HERC4(HERC4) ,partial - CSB-YP682930HU CSB-EP682930HU CSB-BP682930HU CSB-MP682930HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Probable E3 ubiquitin-protein ligase HERC4 (HERC4), partial, Recombinant Protein - MBS1478734 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

HERC4 Recombinant Protein Antigen - NBP1-91984PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

HERC4-Blocking-Peptide-Center - BP21313c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HERC4 Peptide, Human - M34GP06944H from Creative Peptides Category Peptide Source Synthetic. Species Human

HERC4 Recombinant Protein Antigen - NBP2-56037PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

HERC4, Recombinant Protein - MBS515355 from MyBioSource Category Protein Prices $260.00, $415.00 Sizes 20 µg, 50 µg Source Sf9 insect cells using baculovirus Species Human

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