HERC4

Gene Symbol HERC4
Entrez Gene 26091
Alt Symbol -
Species Human
Gene Type protein-coding
Description HECT and RLD domain containing E3 ubiquitin protein ligase 4
Other Description HECT domain and RCC1-like domain-containing protein 4|hect domain and RLD 4|probable E3 ubiquitin-protein ligase HERC4
Swissprots Q5GC99 Q9HCH9 Q5GC98 Q5GLZ8 Q5GCA0 Q8IXP9
Accessions EAW54260 EAW54261 EAW54262 EAW54263 EAW54264 EAW54265 EAW54266 Q5GLZ8 AB046813 BAB13419 AK021844 AK026808 AK027835 AK292809 BAF85498 AL096715 CAB46371 AY221963 AAO65480 AY650032 AAV66578 AY650033 AAV66579 AY650034 AAV66580 BC015043 BC018114 BC039465 BC039600 AAH39600 BX101651 BX537563 DB459623 JF432426 ADZ15643 XM_011539592 XP_011537894 XM_011539593 XP_011537895 XM_011539594 XP_011537896 XM_011539595 XP_011537897 XM_011539596 XP_011537898 XM_011539597 XP_011537899 XM_011539598 XP_011537900 XM_011539599 XP_011537901 NM_001017972 NM_001278185 NP_001265114 NM_001278186 NP_001265115 NM_001278187 NP_001265116 NM_015601 NP_056416 NM_022079 NP_071362
Function Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:15676274}. Note=shows a punctate cytoplasmic distribution.
Tissue Specificity Expressed in brain and testis and detected in heart and placenta. {ECO:0000269|PubMed:15676274}.
Top Pathways Ubiquitin mediated proteolysis

Herc4 (N-13) - sc-164579 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Herc4 (N-13): sc-164579. Western blot analysis of Herc4 expression in HeLa (A), HEK293 (B), NIH/3T3 (C), ACHN (D) and JAR (E) whole cell lysates and mouse testis tissue extract (F).

Anti-HERC4 antibody - ab85732 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HERC4 antibody (ab85732) at 0.1 µg/mlLane 1 : Whole cell lysate from HeLa cells at 50 µgLane 2 : Whole cell lysate from HeLa cells at 15 µgLane 3 : Whole cell lysate from HeLa cells at 5 µgLane 4 : Whole cell lysate from 293T cells at 50 µgLane 5 : Whole cell lysate from NIH3T3 cells at 50 µgdeveloped using the ECL technique

Anti-HERC4 antibody - ab101006 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-HERC4 antibody (ab101006) at 1/1000 dilution + Human fetal brain lysate

Anti-HERC4 antibody - ab113827 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HERC4 antibody - ab57254 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57254 HERC4 antibody at 1ug/ml.

Anti-HERC4 Antibody (aa1007-1057) - LS-C288637 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse HERC4 by Western Blot (h&m) and Immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 ug), and mouse NIH3T3 (M; 50 ug) cells. Antibodies: Affinity purified rabbit anti-HERC4 antibody used for WB at 0.1 ug/ml (A) and 1 ug/ml (B) and used for IP at 3 ug/mg lysate. Detection: Chemiluminescence with exposure times of 30 seconds (A and B).

Anti-HERC4 Antibody - LS-C137355 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HERC4 Antibody (aa341-441) - LS-C308211 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-HERC4 Antibody (aa39-76) - LS-C135125 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HERC4 antibody LS-C135125 Western blot of Fetal Liver lysate. Antibody concentration 1 ug/ml.

Anti-HERC4 Antibody (C-Terminus) - LS-C107994 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HERC4 antibody LS-C107994 Western blot of ACHN lysate.

Anti-HERC4 Antibody (N-Terminus) - LS-C110740 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HERC4 antibody LS-C110740 Western blot of Fetal Liver lysate.

HERC4 Antibody - NBP1-53020 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: HERC4 Antibody [NBP1-53020] - Human Liver cell lysate, concentration 0.2-1 ug/ml.

HERC4 Antibody - NBP1-00104 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: HERC4 Antibody [NBP1-00104] - Detection of Human and Mouse HERC4 on HeLa whole cell lysate using NBP1-00104.

HERC4 Antibody - NBP1-91984 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: HERC4 Antibody [NBP1-91984] - Staining of human stomach, upper shows strong cytoplasmic positivity in subset of glandular cells.

HERC4 Antibody (2G7) - H00026091-M08 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2G7
ELISA: HERC4 Antibody (2G7) [H00026091-M08] - Detection limit for recombinant GST tagged HERC4 is approximately 0.3ng/ml as a capture antibody.

HERC4 Polyclonal Antibody - bs-15462R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Monoclonal Anti-HERC4 antibody produced in mouse - WH0026091M8 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2G7
<B>Immunoblotting</B><BR/>Monoclonal Anti-HERC4, <B>Cat. No. WH0026091M8</B> used at the antibody concentration: 1 μg/mL. Specific band of ~37.11 kDa using immunogen protein lysate.

Anti-HERC4 antibody produced in rabbit - SAB2105507 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-HERC4: <B>Cat. No. SAB2105507</B>: HERC4 in ACHN cell lysates with HERC4 antibody at 1.0 μg/mL.

Anti-HERC4 antibody produced in rabbit - HPA045453 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-HERC4: <B>Cat. No. HPA045453</B>: Immunohistochemical staining of human stomach, upper shows strong cytoplasmic positivity in subset of glandular cells.

HERC4 antibody - N-terminal region (ARP42990_P050) - ARP42990_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HERC4 antibody - middle region (ARP42991_P050) - ARP42991_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HERC4 antibody - middle region (ARP43298_P050) - ARP43298_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HERC4-Antibody-monoclonal-M08 - AT2352a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2G7
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .

HERC4-Antibody-Center - AP21313c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Anti-HERC4 Antibody (Center)at 1:2000 dilution + human testis lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 119 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

HERC4 antibody, Internal - GTX46908 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Anti-HERC4 antibody, Internal used in IHC (Formalin-fixed paraffin-embedded sections). GTX46908
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