HERC4
| Gene Symbol | HERC4 |
|---|---|
| Entrez Gene | 26091 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | HECT and RLD domain containing E3 ubiquitin protein ligase 4 |
| Other Description | HECT domain and RCC1-like domain-containing protein 4|hect domain and RLD 4|probable E3 ubiquitin-protein ligase HERC4 |
| Swissprots | Q5GC99 Q9HCH9 Q5GC98 Q5GLZ8 Q5GCA0 Q8IXP9 |
| Accessions | EAW54260 EAW54261 EAW54262 EAW54263 EAW54264 EAW54265 EAW54266 Q5GLZ8 AB046813 BAB13419 AK021844 AK026808 AK027835 AK292809 BAF85498 AL096715 CAB46371 AY221963 AAO65480 AY650032 AAV66578 AY650033 AAV66579 AY650034 AAV66580 BC015043 BC018114 BC039465 BC039600 AAH39600 BX101651 BX537563 DB459623 JF432426 ADZ15643 XM_011539592 XP_011537894 XM_011539593 XP_011537895 XM_011539594 XP_011537896 XM_011539595 XP_011537897 XM_011539596 XP_011537898 XM_011539597 XP_011537899 XM_011539598 XP_011537900 XM_011539599 XP_011537901 NM_001017972 NM_001278185 NP_001265114 NM_001278186 NP_001265115 NM_001278187 NP_001265116 NM_015601 NP_056416 NM_022079 NP_071362 |
| Function | Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:15676274}. Note=shows a punctate cytoplasmic distribution. |
| Tissue Specificity | Expressed in brain and testis and detected in heart and placenta. {ECO:0000269|PubMed:15676274}. |
| Top Pathways | Ubiquitin mediated proteolysis |
Herc4 CRISPR/Cas9 KO Plasmid (h) - sc-410498 from Santa Cruz Biotechnology
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Herc4 HDR Plasmid (h) - sc-410498-HDR from Santa Cruz Biotechnology
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Herc4 Double Nickase Plasmid (h) - sc-410498-NIC from Santa Cruz Biotechnology
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Herc4 Double Nickase Plasmid (h2) - sc-410498-NIC-2 from Santa Cruz Biotechnology
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Herc4 CRISPR Activation Plasmid (h) - sc-410498-ACT from Santa Cruz Biotechnology
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Herc4 CRISPR Activation Plasmid (h2) - sc-410498-ACT-2 from Santa Cruz Biotechnology
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Herc4 Lentiviral Activation Particles (h) - sc-410498-LAC from Santa Cruz Biotechnology
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Herc4 Lentiviral Activation Particles (h2) - sc-410498-LAC-2 from Santa Cruz Biotechnology
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Herc4 siRNA (h) - sc-90436 from Santa Cruz Biotechnology
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Herc4 shRNA Plasmid (h) - sc-90436-SH from Santa Cruz Biotechnology
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Herc4 shRNA (h) Lentiviral Particles - sc-90436-V from Santa Cruz Biotechnology
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HERC4 RNAi - H00026091-R01 from Novus Biologicals
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MISSION® esiRNA - EHU146151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9985 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9985 from Sigma-Aldrich
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HERC4 siRNA (Human) - CRH8703 from Cohesion Biosciences
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HERC4 RNAi - H00026091-R02 from Novus Biologicals
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HERC4 - MBS8221776 from MyBioSource
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shRNA set against Human HERC4 (NM_015601.3) - SHH311625 from Creative biogene
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shRNA set against Human HERC4(NM_015601.3) - SHH118487 from Creative biogene
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shRNA set against Human HERC4(NM_022079.2) - SHH118505 from Creative biogene
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HERC4 shRNA Plasmid (Human) - CHH8703 from Cohesion Biosciences
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HERC4 miRNA 3'UTR clone - MiUTR1H-04463 from Creative biogene
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HERC4 miRNA 3'UTR clone - MiUTR1H-04464 from Creative biogene
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