| Gene Symbol |
MAD2L2
|
| Entrez Gene |
10459
|
| Alt Symbol |
MAD2B, POLZ2, REV7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MAD2 mitotic arrest deficient-like 2 (yeast)
|
| Other Description |
MAD2 (mitotic arrest deficient, yeast, homolog)-like 2|MAD2-like protein 2|REV7 homolog|hREV7|mitotic arrest deficient 2-like protein 2|mitotic arrest deficient homolog-like 2|mitotic spindle assembly checkpoint protein MAD2B|polymerase (DNA-directed), zeta 2, accessory subunit
|
| Swissprots |
Q9UNA7 Q9Y6I6 Q5TGW7 B3KNE3 Q9UI95
|
| Accessions |
AAY26393 EAW71697 EAW71698 EAW71699 Q9UI95 AF072933 AAD41647 AF080398 AAF20267 AF139365 AAD30290 AF157482 AAF34357 AK027327 BAG51305 AK094316 BAG52858 BC015244 AAH15244 BI517654 DQ891038 ABM81964 DQ894217 ABM85143 XM_011540507 XP_011538809 NM_001127325 NP_001120797 NM_006341 NP_006332
|
| Function |
Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation. {ECO:0000269|PubMed:11459825, ECO:0000269|PubMed:11459826, ECO:0000269|PubMed:17296730, ECO:0000269|PubMed:17719540, ECO:00
|
| Subcellular Location |
Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:11717438}.
|
| Top Pathways |
Cell cycle, Progesterone-mediated oocyte maturation, Oocyte meiosis, Bacterial invasion of epithelial cells
|