| Gene Symbol | MAD2L2 |
|---|---|
| Entrez Gene | 10459 |
| Alt Symbol | MAD2B, POLZ2, REV7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | MAD2 mitotic arrest deficient-like 2 (yeast) |
| Other Description | MAD2 (mitotic arrest deficient, yeast, homolog)-like 2|MAD2-like protein 2|REV7 homolog|hREV7|mitotic arrest deficient 2-like protein 2|mitotic arrest deficient homolog-like 2|mitotic spindle assembly checkpoint protein MAD2B|polymerase (DNA-directed), zeta 2, accessory subunit |
| Swissprots | Q9UNA7 Q9Y6I6 Q5TGW7 B3KNE3 Q9UI95 |
| Accessions | AAY26393 EAW71697 EAW71698 EAW71699 Q9UI95 AF072933 AAD41647 AF080398 AAF20267 AF139365 AAD30290 AF157482 AAF34357 AK027327 BAG51305 AK094316 BAG52858 BC015244 AAH15244 BI517654 DQ891038 ABM81964 DQ894217 ABM85143 XM_011540507 XP_011538809 NM_001127325 NP_001120797 NM_006341 NP_006332 |
| Function | Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation. {ECO:0000269|PubMed:11459825, ECO:0000269|PubMed:11459826, ECO:0000269|PubMed:17296730, ECO:0000269|PubMed:17719540, ECO:00 |
| Subcellular Location | Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:11717438}. |
| Top Pathways | Cell cycle, Progesterone-mediated oocyte maturation, Oocyte meiosis, Bacterial invasion of epithelial cells |
MAD2B CRISPR/Cas9 KO Plasmid (h) - sc-404007 from Santa Cruz Biotechnology
|
||||||||
MAD2B HDR Plasmid (h) - sc-404007-HDR from Santa Cruz Biotechnology
|
||||||||
MAD2B Double Nickase Plasmid (h) - sc-404007-NIC from Santa Cruz Biotechnology
|
||||||||
MAD2B Double Nickase Plasmid (h2) - sc-404007-NIC-2 from Santa Cruz Biotechnology
|
||||||||
MAD2B CRISPR Activation Plasmid (h) - sc-404007-ACT from Santa Cruz Biotechnology
|
||||||||
MAD2B CRISPR Activation Plasmid (h2) - sc-404007-ACT-2 from Santa Cruz Biotechnology
|
||||||||
MAD2B Lentiviral Activation Particles (h) - sc-404007-LAC from Santa Cruz Biotechnology
|
||||||||
MAD2B Lentiviral Activation Particles (h2) - sc-404007-LAC-2 from Santa Cruz Biotechnology
|
||||||||
MAD2B siRNA (h) - sc-106795 from Santa Cruz Biotechnology
|
||||||||
MAD2B shRNA Plasmid (h) - sc-106795-SH from Santa Cruz Biotechnology
|
||||||||
MAD2B shRNA (h) Lentiviral Particles - sc-106795-V from Santa Cruz Biotechnology
|
||||||||
MAD2B siRNA (h2) - sc-270065 from Santa Cruz Biotechnology
|
||||||||
MAD2B shRNA Plasmid (h2) - sc-270065-SH from Santa Cruz Biotechnology
|
||||||||
MAD2B shRNA (h2) Lentiviral Particles - sc-270065-V from Santa Cruz Biotechnology
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN12895 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12895 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR01905 from Sigma-Aldrich
|
||||||||
MAD2L2 siRNA (Human) - CRH7097 from Cohesion Biosciences
|
||||||||
shRNA set against Human MAD2L2 (NM_006341.3) - SHH336543 from Creative biogene
|
||||||||
Human MAD2L2 siRNA - orb267599 from Biorbyt
|
||||||||
MAD2L2 shRNA Plasmid (Human) - CHH7097 from Cohesion Biosciences
|
||||||||
MAD2L2 miRNA 3'UTR clone - MiUTR3H-06538 from Creative biogene
|
||||||||
MAD2L2 miRNA 3'UTR clone - MiUTR3H-06539 from Creative biogene
|