MAD2L2

Gene Symbol	MAD2L2
Entrez Gene	10459
Alt Symbol	MAD2B, POLZ2, REV7
Species	Human
Gene Type	protein-coding
Description	MAD2 mitotic arrest deficient-like 2 (yeast)
Other Description	MAD2 (mitotic arrest deficient, yeast, homolog)-like 2|MAD2-like protein 2|REV7 homolog|hREV7|mitotic arrest deficient 2-like protein 2|mitotic arrest deficient homolog-like 2|mitotic spindle assembly checkpoint protein MAD2B|polymerase (DNA-directed), zeta 2, accessory subunit
Swissprots	Q9UNA7 Q9Y6I6 Q5TGW7 B3KNE3 Q9UI95
Accessions	AAY26393 EAW71697 EAW71698 EAW71699 Q9UI95 AF072933 AAD41647 AF080398 AAF20267 AF139365 AAD30290 AF157482 AAF34357 AK027327 BAG51305 AK094316 BAG52858 BC015244 AAH15244 BI517654 DQ891038 ABM81964 DQ894217 ABM85143 XM_011540507 XP_011538809 NM_001127325 NP_001120797 NM_006341 NP_006332
Function	Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation. {ECO:0000269|PubMed:11459825, ECO:0000269|PubMed:11459826, ECO:0000269|PubMed:17296730, ECO:0000269|PubMed:17719540, ECO:00
Subcellular Location	Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:11717438}.
Top Pathways	Cell cycle, Progesterone-mediated oocyte maturation, Oocyte meiosis, Bacterial invasion of epithelial cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Mad2L2 peptide - ab11254 from Abcam Category Peptide Species Human

MAD2L2 Peptide - NBP1-96764 from Novus Biologicals Category Peptide Prices $169.00 Sizes 50 µg

Mad2L2 (3-14) peptide - GTX11254 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

MAD2L2 Control Peptide - R1541CP from Acris Antibodies Category Peptide Prices $109.00 Sizes 50 µg

MAD2L2 fusion protein - Ag3373 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human MAD2L2, GST-tagged - MAD2L2-683H from Creative Biomart Category Protein Source E.coli Species Human

MAD2L2 Peptide - 000-001-470 from Rockland Immunochemicals Inc Category Peptide Prices $98.00 Sizes 50 µg Species Human

Recombinant Human Mitotic spindle assembly checkpoint protein MAD2B(MAD2L2) - CSB-YP887064HU CSB-EP887064HU CSB-BP887064HU CSB-MP887064HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MAD2L2-Blocking-Peptide-C-term - BP20654c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAD2L2 Peptide, Human - M34GP09065H from Creative Peptides Category Peptide Source Synthetic. Species Human

MAD2L2 Recombinant Protein Antigen - NBP2-58605PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Mitotic spindle assembly checkpoint protein MAD2B (MAD2L2), Recombinant Protein - MBS1395831 from MyBioSource Category Protein Prices $960.00, $960.00, $1,185.00, $1,185.00, $1,440.00, $1,440.00, $1,905.00, $1,905.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

MAD2L2 peptide - orb343875 from Biorbyt Category Peptide Species Human

Recombinant Human MAD2L2 Protein, MYC/DDK-tagged - MAD2L2-685H from Creative Biomart Category Protein Source HEK293 Species Human

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