SREBF1

Gene Symbol	SREBF1
Entrez Gene	6720
Alt Symbol	SREBP-1c, SREBP1, bHLHd1
Species	Human
Gene Type	protein-coding
Description	sterol regulatory element binding transcription factor 1
Other Description	SREBP-1|class D basic helix-loop-helix protein 1|sterol regulatory element-binding protein 1
Swissprots	B0I4X4 Q6PFW7 Q16062 Q8TAK9 P36956 Q59F52 Q6PJ36 B0I4X3 D3DXC4 Q6P4R7
Accessions	EAW55688 EAW55689 EAW55690 EAW55691 P36956 AB209609 BAD92846 AB373958 BAG06742 AB373959 BAG06743 AK091131 BAG52289 AK095325 BAG53027 AK128320 BAG54659 AK293795 BAG57207 AK294800 BAG57920 AK297113 BAG59620 BC023621 AAH23621 BC026962 AAH26962 BC057388 AAH57388 BC063281 AAH63281 BE208013 BI906407 BQ025047 S66167 AAB28522 S66168 AAB28523 U00968 AAC50051 XM_005256772 XP_005256829 XM_006721570 XP_006721633 XM_011523998 XP_011522300 XM_011523999 XP_011522301 XR_429821 NM_001005291 NP_001005291 NM_004176 NP_004167
Function	Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). {ECO:0000250|UniProtKB:Q9WTN3}.
Subcellular Location	Isoform SREBP-1aDelta: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:18267114}.
Tissue Specificity	Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle.
Top Pathways	Insulin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SREBP-1 Transcription Factor Assay Kit - ab133125 from Abcam Category Cellular Assay Prices $494.00 Sizes 96 tests

Human/Rat SREBF1 / SREBP-1 ELISA Kit (Cell-Based ELISA) - LS-F2323 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.391-25 ng/ml

Human/Rat Phospho-SREBF1 / SREBP-1 (Ser439) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1744 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.391-25 ng/ml

SREBP1 Colorimetric Assay Kit - KA1377 from Novus Biologicals Category Assay Kit Prices $659.00 Sizes 1 kit

Sterol regulatory element-binding protein 1 (SREBF1), Human, ELISA Kit - CSB-EL022657HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

SREBF1 Transcription Factor Assay Kit - KA1377 from Acris Antibodies Category ELISA Kit Prices $560.00 Sizes 1 kit

SREBP-1 Colorimetric Cell-Based ELISA Kit - CB5650 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

SREBP-1 (Phospho-Ser439) Colorimetric Cell-Based ELISA Kit - CBP1839 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

sterol regulatory element binding transcription factor 1, ELISA Kit - MBS916923 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.95 pg/ml. Range 7.8 pg/ml -500 pg/ml.

Human Sterol regulatory element-binding protein 1(SREBF1) ELISA kit - CSB-EL022657HU from Cusabio Category ELISA Kit Sensitivity 1.95 pg/ml Range 7.8 pg/ml-500 pg/ml

SREBP-1 ELISA Kit - DEIA-XYA1674 from Creative Diagnostics Category ELISA Kit

SREBP-1 (Phospho-Ser439) ELISA Kit - DEIA-XYA1675 from Creative Diagnostics Category ELISA Kit

Human SREBF1 ELISA Kit - E036739 from Biobool Category ELISA Kit Sensitivity 1.95 pg/ml.

anti-SREBP1 antibody [2A4] - ARG62627 from Arigo Biolaboratories Category ELISA Kit

SREBF1 ELISA Kit (Human) (OKCA01533) - OKCA01533 from Aviva Systems Biology Category ELISA Kit Prices $600.00 Sizes 96 wells Sensitivity 1.95 pg/mL Range 7.8 - 500 pg/mL

Rat SREBF1 / SREBP-1 ELISA Kit (Sandwich ELISA) - LS-F36136 from LifeSpan Bioscience Category ELISA Kit Sensitivity 0.234 Range 0.391-25 ng/ml

Human SREBF1 ELISA Kit - orb406363 from Biorbyt Category ELISA Kit Sensitivity 1.95 pg/ml Range 7.8 pg/ml-500 pg/ml

SREBP-1 Colorimetric Cell-Based ELISA Kit - EKA50559 from Biomatik Category ELISA Kit Prices $399.00 Sizes 96 tests Sensitivity At least 5000 cells/well Range Qualitative

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