SREBF1

Gene Symbol	SREBF1
Entrez Gene	6720
Alt Symbol	SREBP-1c, SREBP1, bHLHd1
Species	Human
Gene Type	protein-coding
Description	sterol regulatory element binding transcription factor 1
Other Description	SREBP-1|class D basic helix-loop-helix protein 1|sterol regulatory element-binding protein 1
Swissprots	B0I4X4 Q6PFW7 Q16062 Q8TAK9 P36956 Q59F52 Q6PJ36 B0I4X3 D3DXC4 Q6P4R7
Accessions	EAW55688 EAW55689 EAW55690 EAW55691 P36956 AB209609 BAD92846 AB373958 BAG06742 AB373959 BAG06743 AK091131 BAG52289 AK095325 BAG53027 AK128320 BAG54659 AK293795 BAG57207 AK294800 BAG57920 AK297113 BAG59620 BC023621 AAH23621 BC026962 AAH26962 BC057388 AAH57388 BC063281 AAH63281 BE208013 BI906407 BQ025047 S66167 AAB28522 S66168 AAB28523 U00968 AAC50051 XM_005256772 XP_005256829 XM_006721570 XP_006721633 XM_011523998 XP_011522300 XM_011523999 XP_011522301 XR_429821 NM_001005291 NP_001005291 NM_004176 NP_004167
Function	Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). {ECO:0000250|UniProtKB:Q9WTN3}.
Subcellular Location	Isoform SREBP-1aDelta: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:18267114}.
Tissue Specificity	Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle.
Top Pathways	Insulin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SREBP1 peptide - ab45062 from Abcam Category Peptide

Human SREBP1 protein fragment - ab159577 from Abcam Category Protein Source Wheat germ Species Human

Mouse SREBP1 peptide - ab31099 from Abcam Category Peptide Species Mouse

SREBF1 / SREBP-1 Antibody Blocking Peptide - LS-E10648 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SREBF1 / SREBP-1 Antibody Blocking Peptide - LS-E13804 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SREBF1 / SREBP-1 Antibody Blocking Peptide - LS-E9748 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SREBP1 Blocking Peptide - NB100-60545PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

SREBP1 Blocking Peptide - NB100-2215PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

SREBP1 Partial Recombinant Protein - H00006720-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SREBF1-Antibody-Center-Blocking-Peptide - BP8732c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SREBF1 Protein Lysate (APL10444) - APL10444 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

SREBF1 Protein Lysate (APL10609) - APL10609 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

SREBF1 Protein Lysate (APL10610) - APL10610 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

SREBF1 Blocking Peptide - 33R-1852 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SREBF1 Blocking Peptide - 33R-1993 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SREBP1 Blocking Peptide - 33R-11032 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

SREBF1 / SREBP1 - H00006720-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SREBF1 / SREBP1 - H00006720-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SREBF1 Peptide - 7853P from ProSci Category Peptide Species Human

SREBF1 fusion protein - ag5484 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

SREBF1 fusion protein - ag5219 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SREBP1 Blocking Peptide - 3961BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

Recombinant Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) - RPC868Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

SREBP1 (pS439) Blocking Peptide - abx162044 from Abbexa Category Peptide Species Human, Mouse, Rat, Pig

SREBF1 Protein Lysate - orb333475 from Biorbyt Category Protein Prices $400.00 Sizes 200 μg Species Human

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