| Gene Symbol | SREBF1 |
|---|---|
| Entrez Gene | 6720 |
| Alt Symbol | SREBP-1c, SREBP1, bHLHd1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | sterol regulatory element binding transcription factor 1 |
| Other Description | SREBP-1|class D basic helix-loop-helix protein 1|sterol regulatory element-binding protein 1 |
| Swissprots | B0I4X4 Q6PFW7 Q16062 Q8TAK9 P36956 Q59F52 Q6PJ36 B0I4X3 D3DXC4 Q6P4R7 |
| Accessions | EAW55688 EAW55689 EAW55690 EAW55691 P36956 AB209609 BAD92846 AB373958 BAG06742 AB373959 BAG06743 AK091131 BAG52289 AK095325 BAG53027 AK128320 BAG54659 AK293795 BAG57207 AK294800 BAG57920 AK297113 BAG59620 BC023621 AAH23621 BC026962 AAH26962 BC057388 AAH57388 BC063281 AAH63281 BE208013 BI906407 BQ025047 S66167 AAB28522 S66168 AAB28523 U00968 AAC50051 XM_005256772 XP_005256829 XM_006721570 XP_006721633 XM_011523998 XP_011522300 XM_011523999 XP_011522301 XR_429821 NM_001005291 NP_001005291 NM_004176 NP_004167 |
| Function | Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). {ECO:0000250|UniProtKB:Q9WTN3}. |
| Subcellular Location | Isoform SREBP-1aDelta: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:18267114}. |
| Tissue Specificity | Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle. |
| Top Pathways | Insulin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway |
SREBP-1 CRISPR/Cas9 KO Plasmid (h) - sc-400094 from Santa Cruz Biotechnology
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SREBP-1 HDR Plasmid (h) - sc-400094-HDR from Santa Cruz Biotechnology
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SREBP-1 Double Nickase Plasmid (h) - sc-400094-NIC from Santa Cruz Biotechnology
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SREBP-1 Double Nickase Plasmid (h2) - sc-400094-NIC-2 from Santa Cruz Biotechnology
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SREBP-1 CRISPR Activation Plasmid (h) - sc-400094-ACT from Santa Cruz Biotechnology
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SREBP-1 CRISPR Activation Plasmid (h2) - sc-400094-ACT-2 from Santa Cruz Biotechnology
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SREBP-1 Lentiviral Activation Particles (h) - sc-400094-LAC from Santa Cruz Biotechnology
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SREBP-1 Lentiviral Activation Particles (h2) - sc-400094-LAC-2 from Santa Cruz Biotechnology
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SREBP-1 siRNA (h) - sc-36557 from Santa Cruz Biotechnology
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SREBP-1 shRNA Plasmid (h) - sc-36557-SH from Santa Cruz Biotechnology
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SREBP-1 shRNA (h) Lentiviral Particles - sc-36557-V from Santa Cruz Biotechnology
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SREBP-1 siRNA (h2) - sc-44327 from Santa Cruz Biotechnology
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SREBP-1 shRNA Plasmid (h2) - sc-44327-SH from Santa Cruz Biotechnology
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SREBP-1 shRNA (h2) Lentiviral Particles - sc-44327-V from Santa Cruz Biotechnology
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SREBP1 RNAi - H00006720-R01 from Novus Biologicals
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SREBP1 RNAi - H00006720-R02 from Novus Biologicals
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MISSION® esiRNA - EHU084811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1345 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1345 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03964 from Sigma-Aldrich
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SREBF1 siRNA (Human) - CRH4588 from Cohesion Biosciences
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SREBF1 - MBS8209319 from MyBioSource
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SREBP-1 HDR Plasmid (h2) - sc-400094-HDR-2 from Santa Cruz Biotechnology
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SREBP-1 CRISPR/Cas9 KO Plasmid (h2) - sc-400094-KO-2 from Santa Cruz Biotechnology
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Human SREBF1 siRNA - orb265090 from Biorbyt
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