Gene Symbol | CHST8 |
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Entrez Gene | 64377 |
Alt Symbol | GALNAC4ST1, GalNAc4ST, PSS3 |
Species | Human |
Gene Type | protein-coding |
Description | carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 |
Other Description | GALNAC-4-ST1|GalNAc-4-O-sulfotransferase 1|N-acetylgalactosamine-4-O-sulfotransferase 1|carbohydrate sulfotransferase 8|galNAc4ST-1 |
Swissprots | Q9H2A9 Q9H3N2 |
Accessions | Q9H2A9 AB047801 BAB19806 AF300612 AAG39444 AF305781 AAL09373 BC011380 AAH11380 BC014250 AAH14250 BC018723 AAH18723 BI917117 BX354555 DB500322 DQ891438 ABM82364 DQ894614 ABM85540 XM_011527220 XP_011525522 XM_011527221 XP_011525523 XM_011527222 XP_011525524 XM_011527223 XP_011525525 XM_011527224 XP_011525526 XM_011527225 XP_011525527 XM_011527226 XP_011525528 NM_001127895 NP_001121367 NM_001127896 NP_001121368 NM_022467 NP_071912 |
Function | Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin. {ECO:0000269|PubMed:10988300, ECO:0000269|PubMed:11445554}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | Predominantly expressed in pituitary gland. In brain, it is expressed in pituitary gland, cerebellum, medulla oblongata, pons, thalamus and spinal cord. Expressed in the epidermis. Expressed at lower level in lung, spleen, adrenal gland, placenta, prostate, testis, mammary gland and trachea. {ECO:0000269|PubMed:10988300, ECO:0000269|PubMed:11001942, ECO:0000269|PubMed:11445554, ECO:0000269|PubMed:22289416}. |
GalNAc4ST-1 (C-20) - sc-49012 from Santa Cruz Biotechnology
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GalNAc4ST-1 (H-86) - sc-368462 from Santa Cruz Biotechnology
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Anti-CHST8 antibody - ab136034 from Abcam
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Anti-CHST8 antibody - ab171322 from Abcam
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Anti-CHST8 antibody - ab69064 from Abcam
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Anti-CHST8 antibody - ab104923 from Abcam
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Anti-GALNAC4ST1 / CHST8 Antibody (aa219-247) - LS-C168766 from LifeSpan Bioscience
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Anti-GALNAC4ST1 / CHST8 Antibody (aa341-390) - LS-C119806 from LifeSpan Bioscience
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Anti-GALNAC4ST1 / CHST8 Antibody (aa219-247, APC) - LS-C233837 from LifeSpan Bioscience
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Anti-GALNAC4ST1 / CHST8 Antibody (aa219-247, FITC) - LS-C233838 from LifeSpan Bioscience
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Anti-GALNAC4ST1 / CHST8 Antibody (aa219-247, Biotin) - LS-C233839 from LifeSpan Bioscience
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Anti-GALNAC4ST1 / CHST8 Antibody (aa219-247, PE) - LS-C233840 from LifeSpan Bioscience
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Anti-GALNAC4ST1 / CHST8 Antibody (aa219-247, AP) - LS-C249045 from LifeSpan Bioscience
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Anti-GALNAC4ST1 / CHST8 Antibody (aa219-247, Azide-free, HRP) - LS-C249674 from LifeSpan Bioscience
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Anti-GALNAC4ST1 / CHST8 Antibody (aa333-382) - LS-C291801 from LifeSpan Bioscience
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Anti-GALNAC4ST1 / CHST8 Antibody (aa226-255) - LS-C320387 from LifeSpan Bioscience
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Anti-GALNAC4ST1 / CHST8 Antibody (aa201-250) - LS-C81440 from LifeSpan Bioscience
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CHST8 Antibody - NBP1-83396 from Novus Biologicals
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CHST8 Antibody - NBP1-69273 from Novus Biologicals
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CHST8 Antibody - H00064377-B01 from Novus Biologicals
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Anti-CHST8 antibody produced in rabbit - HPA016004 from Sigma-Aldrich
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Anti-CHST8 antibody produced in rabbit - AV49723 from Sigma-Aldrich
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Anti-CHST8, C-Terminal antibody produced in rabbit - SAB4502754 from Sigma-Aldrich
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CHST8 antibody - middle region (ARP49723_P050) - ARP49723_P050 from Aviva Systems Biology
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CHST8-Antibody-Center - AP12842c from Abgent, a WuXi AppTec company
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