SPDL1

Gene Symbol	SPDL1
Entrez Gene	54908
Alt Symbol	CCDC99
Species	Human
Gene Type	protein-coding
Description	spindle apparatus coiled-coil protein 1
Other Description	arsenite-related gene 1 protein|coiled-coil domain containing 99|coiled-coil domain-containing protein 99|hSpindly|protein Spindly|rhabdomyosarcoma antigen MU-RMS-40.4A|rrhabdomyosarcoma antigen protein MU-RMS-40.4A|spindle apparatus coiled-coil domain-containing protein 1|spindly homolog
Swissprots	Q9NX97 Q96EA4 C9JS47 B4E393 Q9HD44 Q8TEC8
Accessions	EAW61495 EAW61496 Q96EA4 AF269167 AAG01408 AK000371 BAA91119 AK055287 AK074227 BAB85022 AK098009 AK304623 BAG65405 AK308835 AK310442 AY517557 AAT44530 BC012568 AAH12568 BP295943 BU166207 CA417197 CD653505 DC379275 JF432342 ADZ15559 XM_011534585 XP_011532887 XM_011534586 XP_011532888 XM_011534587 XP_011532889 XM_011534588 XP_011532890 XM_011534589 XP_011532891 XM_011534590 XP_011532892 NM_017785 NP_060255
Function	Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. {ECO:0000255|HAMAP-Rule:MF_03041, ECO:0000269|PubMed:17576797, ECO:0000269|PubMed:19468067}.
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SPDL-1 (P-19) - sc-242388 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SPDL-1 (S-19) - sc-242387 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Spindly antibody - ab99344 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Spindly antibody - ab76670 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-Spindly antibody - ab116002 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Spindly antibody - ab136045 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Spindly antibody - C-terminal - ab197682 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SPDL1 / CCDC99 Antibody (aa459-488, APC) - LS-C233519 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SPDL1 / CCDC99 Antibody (aa459-488, AP) - LS-C233518 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SPDL1 / CCDC99 Antibody (aa459-488, Biotin) - LS-C233520 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SPDL1 / CCDC99 Antibody (aa459-488, FITC) - LS-C233521 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SPDL1 / CCDC99 Antibody (aa459-488, PE) - LS-C233522 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SPDL1 / CCDC99 Antibody (aa459-488, Azide-free, HRP) - LS-C249603 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SPDL1 / CCDC99 Antibody (aa475-525) - LS-C288162 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SPDL1 / CCDC99 Antibody (aa541-590) - LS-C291315 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SPDL1 / CCDC99 Antibody (aa525-575) - LS-C288169 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SPDL1 / CCDC99 Antibody (aa532-581) - LS-C291767 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SPDL1 / CCDC99 Antibody (aa458-488) - LS-C320089 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SPDL1 / CCDC99 Antibody (C-Terminus) - LS-C169955 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SPDL1 / CCDC99 Antibody (aa459-488) - LS-C168446 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

CCDC99 Antibody (2F4) - H00054908-M01 from Novus Biologicals Prices $349.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2F4

CCDC99 Antibody - NB100-61594 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CCDC99 Antibody - NB100-61595 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CCDC99 Antibody - H00054908-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Spindly/CCDC99 Polyclonal Antibody - bs-2321R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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