SPDL1

Gene Symbol SPDL1
Entrez Gene 54908
Alt Symbol CCDC99
Species Human
Gene Type protein-coding
Description spindle apparatus coiled-coil protein 1
Other Description arsenite-related gene 1 protein|coiled-coil domain containing 99|coiled-coil domain-containing protein 99|hSpindly|protein Spindly|rhabdomyosarcoma antigen MU-RMS-40.4A|rrhabdomyosarcoma antigen protein MU-RMS-40.4A|spindle apparatus coiled-coil domain-containing protein 1|spindly homolog
Swissprots Q9NX97 Q96EA4 C9JS47 B4E393 Q9HD44 Q8TEC8
Accessions EAW61495 EAW61496 Q96EA4 AF269167 AAG01408 AK000371 BAA91119 AK055287 AK074227 BAB85022 AK098009 AK304623 BAG65405 AK308835 AK310442 AY517557 AAT44530 BC012568 AAH12568 BP295943 BU166207 CA417197 CD653505 DC379275 JF432342 ADZ15559 XM_011534585 XP_011532887 XM_011534586 XP_011532888 XM_011534587 XP_011532889 XM_011534588 XP_011532890 XM_011534589 XP_011532891 XM_011534590 XP_011532892 NM_017785 NP_060255
Function Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. {ECO:0000255|HAMAP-Rule:MF_03041, ECO:0000269|PubMed:17576797, ECO:0000269|PubMed:19468067}.
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex.

Human Spindly full length protein - ab162888 from Abcam

Category Protein
Source Wheat germ
Species Human
ab162888 on a 12.5% SDS-PAGE stained with Coomassie Blue.

CCDC99 Antibody Blocking Peptide - LS-E2475 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CCDC99 Antibody Blocking Peptide - LS-E24417 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CCDC99 Recombinant Protein - H00054908-P01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

CCDC99-Antibody-C-term-Blocking-peptide - BP13504b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

Spindly / CCDC99 - H00054908-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

Spindly / CCDC99 - H00054908-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

CCDC99 fusion protein - ag20439 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

CCDC99 fusion protein - Ag20430 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

Recombinant Human SPDL1 - SPDL1-1394H from Creative Biomart

Category Protein
Source Mammalian Cells
Species Human

Recombinant Human Protein Spindly(CCDC99) - CSB-YP842662HU CSB-EP842662HU CSB-BP842662HU CSB-MP842662HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Spindly / CCDC99 - TP303078 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
Spindly / CCDC99

CCDC99 Recombinant Protein Antigen - NBP2-47518PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

CCDC99 Recombinant Protein Antigen - NBP2-47517PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

CCDC99 Blocking Peptide - abx162093 from Abbexa

Category Peptide
Species Human, Mouse

SPDL1 Peptide, Human - M34GP15019H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

CCDC99 Blocking Peptide - CBP4882 from Cohesion Biosciences

Category Peptide
Prices $100.00, $300.00
Sizes 1 mg, 5 mg
Species Human, Mouse

Protein Spindly (CCDC99), Recombinant Protein - MBS1302120 from MyBioSource

Category Protein
Prices $1,400.00, $1,400.00, $1,625.00, $1,625.00, $2,355.00, $2,355.00, $2,800.00, $2,800.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

CCDC99 peptide - orb316026 from Biorbyt

Category Peptide
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