SPDL1

Gene Symbol SPDL1
Entrez Gene 54908
Alt Symbol CCDC99
Species Human
Gene Type protein-coding
Description spindle apparatus coiled-coil protein 1
Other Description arsenite-related gene 1 protein|coiled-coil domain containing 99|coiled-coil domain-containing protein 99|hSpindly|protein Spindly|rhabdomyosarcoma antigen MU-RMS-40.4A|rrhabdomyosarcoma antigen protein MU-RMS-40.4A|spindle apparatus coiled-coil domain-containing protein 1|spindly homolog
Swissprots Q9NX97 Q96EA4 C9JS47 B4E393 Q9HD44 Q8TEC8
Accessions EAW61495 EAW61496 Q96EA4 AF269167 AAG01408 AK000371 BAA91119 AK055287 AK074227 BAB85022 AK098009 AK304623 BAG65405 AK308835 AK310442 AY517557 AAT44530 BC012568 AAH12568 BP295943 BU166207 CA417197 CD653505 DC379275 JF432342 ADZ15559 XM_011534585 XP_011532887 XM_011534586 XP_011532888 XM_011534587 XP_011532889 XM_011534588 XP_011532890 XM_011534589 XP_011532891 XM_011534590 XP_011532892 NM_017785 NP_060255
Function Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. {ECO:0000255|HAMAP-Rule:MF_03041, ECO:0000269|PubMed:17576797, ECO:0000269|PubMed:19468067}.
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex.

Human-CCDC99-cDNA-Clone - DC03445 from Abgent, a WuXi AppTec company

Prices $816.75
Sizes 10 µg
Species Human
Accession BC012568

CCDC99 - MBS1270124 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC012568

Human SPDL1 Gene cDNA Clone (full-length ORF Clone) - HG16551-U from Sino Biological

Species Human
Accession NM_017785.4

Human SPDL1 natural ORF mammalian expression plasmid, C-GFPSpark tag - HG16551-ACG from Sino Biological

Species Human
Accession NM_017785.4

Human SPDL1 natural ORF mammalian expression plasmid, N-HA tag - HG16551-NY from Sino Biological

Species Human
Accession NM_017785.4

Human SPDL1 natural ORF mammalian expression plasmid, N-GFPSpark tag - HG16551-ANG from Sino Biological

Species Human
Accession NM_017785.4

Human SPDL1 natural ORF mammalian expression plasmid, N-Flag tag - HG16551-NF from Sino Biological

Species Human
Accession NM_017785.4

Human SPDL1 natural ORF mammalian expression plasmid, C-OFPSpark / RFP tag - HG16551-ACR from Sino Biological

Species Human
Accession NM_017785.4

Human SPDL1 natural ORF mammalian expression plasmid, N-OFPSpark tag - HG16551-ANR from Sino Biological

Species Human
Accession NM_017785.4

Human CCDC99 ORF Clone (BC012568) - CDCS414497 from Creative biogene

Species Human
Accession Q96EA4
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