| Gene Symbol |
SPDL1
|
| Entrez Gene |
54908
|
| Alt Symbol |
CCDC99
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
spindle apparatus coiled-coil protein 1
|
| Other Description |
arsenite-related gene 1 protein|coiled-coil domain containing 99|coiled-coil domain-containing protein 99|hSpindly|protein Spindly|rhabdomyosarcoma antigen MU-RMS-40.4A|rrhabdomyosarcoma antigen protein MU-RMS-40.4A|spindle apparatus coiled-coil domain-containing protein 1|spindly homolog
|
| Swissprots |
Q9NX97 Q96EA4 C9JS47 B4E393 Q9HD44 Q8TEC8
|
| Accessions |
EAW61495 EAW61496 Q96EA4 AF269167 AAG01408 AK000371 BAA91119 AK055287 AK074227 BAB85022 AK098009 AK304623 BAG65405 AK308835 AK310442 AY517557 AAT44530 BC012568 AAH12568 BP295943 BU166207 CA417197 CD653505 DC379275 JF432342 ADZ15559 XM_011534585 XP_011532887 XM_011534586 XP_011532888 XM_011534587 XP_011532889 XM_011534588 XP_011532890 XM_011534589 XP_011532891 XM_011534590 XP_011532892 NM_017785 NP_060255
|
| Function |
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. {ECO:0000255|HAMAP-Rule:MF_03041, ECO:0000269|PubMed:17576797, ECO:0000269|PubMed:19468067}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex.
|
![Western Blot: CCDC99 Overexpression Lysate (Adult Normal) [NBP2-06925] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CCDC99.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5572_CCDC99%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06925-img0001.jpg)