| Gene Symbol |
GPAA1
|
| Entrez Gene |
8733
|
| Alt Symbol |
GAA1, hGAA1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glycosylphosphatidylinositol anchor attachment 1
|
| Other Description |
GAA1 protein homolog|GPAA1P anchor attachment protein 1 homolog|GPI anchor attachment protein 1|GPI transamidase subunit|anchor attachment protein 1 (Gaa1p, yeast) homolog|glycophosphatidylinositol anchor attachment 1|glycosylphosphatidylinositol anchor attachment 1 protein|glycosylphosphatidylinositol anchor attachment protein 1 homolog
|
| Swissprots |
Q9UQ31 O43292 Q9NSS0
|
| Accessions |
BAA82587 BAA82590 CAH05399 EAW82161 EAW82162 EAW82163 EAW82164 EAW82165 O43292 AB002135 BAA82588 AB006969 BAA24035 AK312759 BAG35625 AL157437 CAB75660 BC003171 AAH03171 BC004129 AAH04129 BC006383 AAH06383 DQ895039 ABM85965 EU176312 ABW03763 NM_003801 NP_003792
|
| Function |
Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. {ECO:0000269|PubMed:9468317}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:11483512}; Multi-pass membrane protein {ECO:0000269|PubMed:11483512}.
|
| Tissue Specificity |
Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues. {ECO:0000269|PubMed:9468317}.
|
| Top Pathways |
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
|