Gene Symbol | GPAA1 |
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Entrez Gene | 8733 |
Alt Symbol | GAA1, hGAA1 |
Species | Human |
Gene Type | protein-coding |
Description | glycosylphosphatidylinositol anchor attachment 1 |
Other Description | GAA1 protein homolog|GPAA1P anchor attachment protein 1 homolog|GPI anchor attachment protein 1|GPI transamidase subunit|anchor attachment protein 1 (Gaa1p, yeast) homolog|glycophosphatidylinositol anchor attachment 1|glycosylphosphatidylinositol anchor attachment 1 protein|glycosylphosphatidylinositol anchor attachment protein 1 homolog |
Swissprots | Q9UQ31 O43292 Q9NSS0 |
Accessions | BAA82587 BAA82590 CAH05399 EAW82161 EAW82162 EAW82163 EAW82164 EAW82165 O43292 AB002135 BAA82588 AB006969 BAA24035 AK312759 BAG35625 AL157437 CAB75660 BC003171 AAH03171 BC004129 AAH04129 BC006383 AAH06383 DQ895039 ABM85965 EU176312 ABW03763 NM_003801 NP_003792 |
Function | Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. {ECO:0000269|PubMed:9468317}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:11483512}; Multi-pass membrane protein {ECO:0000269|PubMed:11483512}. |
Tissue Specificity | Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues. {ECO:0000269|PubMed:9468317}. |
Top Pathways | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
GPAA1 CRISPR/Cas9 KO Plasmid (h) - sc-411203 from Santa Cruz Biotechnology
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GPAA1 HDR Plasmid (h) - sc-411203-HDR from Santa Cruz Biotechnology
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GPAA1 Double Nickase Plasmid (h) - sc-411203-NIC from Santa Cruz Biotechnology
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GPAA1 Double Nickase Plasmid (h2) - sc-411203-NIC-2 from Santa Cruz Biotechnology
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GPAA1 CRISPR Activation Plasmid (h) - sc-411203-ACT from Santa Cruz Biotechnology
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GPAA1 CRISPR Activation Plasmid (h2) - sc-411203-ACT-2 from Santa Cruz Biotechnology
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GPAA1 Lentiviral Activation Particles (h) - sc-411203-LAC from Santa Cruz Biotechnology
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GPAA1 Lentiviral Activation Particles (h2) - sc-411203-LAC-2 from Santa Cruz Biotechnology
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GPAA1 siRNA (h) - sc-60715 from Santa Cruz Biotechnology
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GPAA1 shRNA Plasmid (h) - sc-60715-SH from Santa Cruz Biotechnology
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GPAA1 shRNA (h) Lentiviral Particles - sc-60715-V from Santa Cruz Biotechnology
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GPAA1 RNAi - H00008733-R01 from Novus Biologicals
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MISSION® esiRNA - EHU093371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9501 from Sigma-Aldrich
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GPAA1 siRNA (Human) - CRH5752 from Cohesion Biosciences
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GPAA1 - MBS8213194 from MyBioSource
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shRNA set against Human GPAA1 (NM_003801.3) - SHH305602 from Creative biogene
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shRNA set against Human GPAA1(NM_003801.3) - SHH095393 from Creative biogene
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Human GPAA1 siRNA - orb266254 from Biorbyt
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GPAA1 shRNA Plasmid (Human) - CHH5752 from Cohesion Biosciences
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GPAA1 miRNA 3'UTR clone - MiUTR1H-04156 from Creative biogene
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