| Gene Symbol |
HS3ST1
|
| Entrez Gene |
9957
|
| Alt Symbol |
3OST, 3OST1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
|
| Other Description |
3-OST-1|h3-OST-1|heparan sulfate 3-O-sulfotransferase 1|heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1|heparan sulfate glucosamine 3-O-sulfotransferase 1|heparin-glucosamine 3-O-sulfotransferase
|
| Swissprots |
B3KUA6 O14792 Q6PEY8
|
| Accessions |
EAW92699 EAW92700 EAW92701 EAW92702 O14792 AA825270 AF019386 AAB84388 AI478981 AK096823 BAG53368 BC025735 AAH25735 BC057803 AAH57803 BM547276 HQ448559 ADQ33038 XM_011513913 XP_011512215 NM_005114 NP_005105
|
| Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. {ECO:0000269|PubMed:9346953}.
|
| Subcellular Location |
Golgi apparatus lumen {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in the brain and kidney and weakly expressed in the heart, lung and placenta. {ECO:0000269|PubMed:9988767}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
|