Gene Symbol | HS3ST1 |
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Entrez Gene | 9957 |
Alt Symbol | 3OST, 3OST1 |
Species | Human |
Gene Type | protein-coding |
Description | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 |
Other Description | 3-OST-1|h3-OST-1|heparan sulfate 3-O-sulfotransferase 1|heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1|heparan sulfate glucosamine 3-O-sulfotransferase 1|heparin-glucosamine 3-O-sulfotransferase |
Swissprots | B3KUA6 O14792 Q6PEY8 |
Accessions | EAW92699 EAW92700 EAW92701 EAW92702 O14792 AA825270 AF019386 AAB84388 AI478981 AK096823 BAG53368 BC025735 AAH25735 BC057803 AAH57803 BM547276 HQ448559 ADQ33038 XM_011513913 XP_011512215 NM_005114 NP_005105 |
Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. {ECO:0000269|PubMed:9346953}. |
Subcellular Location | Golgi apparatus lumen {ECO:0000305}. |
Tissue Specificity | Highly expressed in the brain and kidney and weakly expressed in the heart, lung and placenta. {ECO:0000269|PubMed:9988767}. |
Top Pathways | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
Human HS3ST1 full length protein - ab160739 from Abcam
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Human HS3ST1 full length protein - ab171694 from Abcam
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Human HS3ST1 protein fragment - ab160740 from Abcam
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HS3ST1 Antibody Blocking Peptide - LS-E11657 from LifeSpan Bioscience
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Heparan Sulfate 3-O-Sulfotransferase 1/HS3ST1 Partial Recombinant Protein - H00009957-Q01 from Novus Biologicals
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Heparan Sulfate 3-O-Sulfotransferase 1/HS3ST1 Recombinant Protein - H00009957-P01 from Novus Biologicals
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Recombinant Human Heparan Sulfate 3-O-Sulfotransferase 1/HS3ST1 Protein - NBP2-23116 from Novus Biologicals
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HS3ST1-Antibody-C-term-Blocking-peptide - BP13378b from Abgent, a WuXi AppTec company
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Recombinant Human HS3ST1, CF - 5968-ST-020 from R&D Systems
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Human HS3ST1 (His Tag) protein - orb179748 from Biorbyt
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HS3ST1 Blocking Peptide - 33R-9139 from Fitzgerald
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HS3ST1 protein (His tag) - 80R-3026 from Fitzgerald
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HS3ST1 / 3OST (21-307, His-tag) - AR51144PU-N from Acris Antibodies
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HS3ST1 / 3OST (21-307, His-tag) - AR51144PU-S from Acris Antibodies
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HS3ST1 / 3OST - H00009957-P01-10 from Acris Antibodies
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HS3ST1 / 3OST - H00009957-P01-25 from Acris Antibodies
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HS3ST1 / 3OST - H00009957-Q01-10 from Acris Antibodies
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HS3ST1 / 3OST - H00009957-Q01-25 from Acris Antibodies
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HS3ST1, 21-307aa, Human, His tag, E.coli - 01-P2320 from ARP American Research Products
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HS3ST1 fusion protein - Ag5719 from Proteintech Group
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HS3ST1 fusion protein - ag5564 from Proteintech Group
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Recombinant Human Heparan Sulfate (glucosamine) 3-O-Sulfotransferase 1, His-tagged - HS3ST1-1970H from Creative Biomart
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Recombinant Human HS3ST1, His-tagged - HS3ST1-13943H from Creative Biomart
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Recombinant Human HS3ST1, His-tagged - HS3ST1-2320H from Creative Biomart
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Recombinant Human HS3ST1, His-tagged - HS3ST1-926H from Creative Biomart
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