| Gene Symbol |
HIST1H1B
|
| Entrez Gene |
3009
|
| Alt Symbol |
H1, H1.5, H1B, H1F5, H1s-3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histone cluster 1, H1b
|
| Other Description |
H1 histone family, member 5|histone 1, H1b|histone H1.5|histone H1a|histone H1b|histone H1s-3
|
| Swissprots |
Q3MJ42 P16401 Q14529
|
| Accessions |
AAA35943 AAN06704 CAA29930 CAA58498 EAX03119 P16401 BC069101 AAH69101 BC101581 AAI01582 BC101583 AAI01584 EU446959 ABZ92488 NM_005322 NP_005313
|
| Function |
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in heterochromatin. According to PubMed:10997781 associates with actively transcribed chromatin and not heterochromatin.
|
| Tissue Specificity |
Ubiquitous. Expressed in the majority of the cell lines tested and in testis. {ECO:0000269|PubMed:9031620}.
|
![Western Blot: Histone H1.5 Overexpression Lysate (Adult Normal) [NBL1-11552] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Histone H1.5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5490_Histone%2520H1.5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11552-img0002.jpg)