Gene Symbol | HIST1H1B |
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Entrez Gene | 3009 |
Alt Symbol | H1, H1.5, H1B, H1F5, H1s-3 |
Species | Human |
Gene Type | protein-coding |
Description | histone cluster 1, H1b |
Other Description | H1 histone family, member 5|histone 1, H1b|histone H1.5|histone H1a|histone H1b|histone H1s-3 |
Swissprots | Q3MJ42 P16401 Q14529 |
Accessions | AAA35943 AAN06704 CAA29930 CAA58498 EAX03119 P16401 BC069101 AAH69101 BC101581 AAI01582 BC101583 AAI01584 EU446959 ABZ92488 NM_005322 NP_005313 |
Function | Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in heterochromatin. According to PubMed:10997781 associates with actively transcribed chromatin and not heterochromatin. |
Tissue Specificity | Ubiquitous. Expressed in the majority of the cell lines tested and in testis. {ECO:0000269|PubMed:9031620}. |
Histone H1 CRISPR/Cas9 KO Plasmid (h) - sc-404845 from Santa Cruz Biotechnology
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Histone H1 HDR Plasmid (h) - sc-404845-HDR from Santa Cruz Biotechnology
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Histone H1 Double Nickase Plasmid (h) - sc-404845-NIC from Santa Cruz Biotechnology
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Histone H1 Double Nickase Plasmid (h2) - sc-404845-NIC-2 from Santa Cruz Biotechnology
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Histone H1 CRISPR Activation Plasmid (h) - sc-404845-ACT from Santa Cruz Biotechnology
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Histone H1 CRISPR Activation Plasmid (h2) - sc-404845-ACT-2 from Santa Cruz Biotechnology
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Histone H1 Lentiviral Activation Particles (h) - sc-404845-LAC from Santa Cruz Biotechnology
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Histone H1 Lentiviral Activation Particles (h2) - sc-404845-LAC-2 from Santa Cruz Biotechnology
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Histone cluster 1 H1B siRNA (h) - sc-37968 from Santa Cruz Biotechnology
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Histone cluster 1 H1B shRNA Plasmid (h) - sc-37968-SH from Santa Cruz Biotechnology
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Histone cluster 1 H1B shRNA (h) Lentiviral Particles - sc-37968-V from Santa Cruz Biotechnology
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Histone H1.5 RNAi - H00003009-R01 from Novus Biologicals
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MISSION® esiRNA - EHU147141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10051 from Sigma-Aldrich
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HIST1H1B siRNA (Human) - CRH2044 from Cohesion Biosciences
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HIST1H1B - MBS8228045 from MyBioSource
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shRNA set against Human HIST1H1B (NM_005322.2) - SHH312369 from Creative biogene
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shRNA set against Human HIST1H1B(NM_005322.2) - SHH121547 from Creative biogene
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Human HIST1H1B siRNA - orb262546 from Biorbyt
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HIST1H1B shRNA Plasmid (Human) - CHH2044 from Cohesion Biosciences
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HIST1H1B miRNA 3'UTR clone - MiUTR1H-04514 from Creative biogene
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