| Gene Symbol |
CYP2W1
|
| Entrez Gene |
54905
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 2, subfamily W, polypeptide 1
|
| Other Description |
CYPIIW1|cytochrome P450 2W1
|
| Swissprots |
Q8TAV3
|
| Accessions |
EAW87186 EAW87187 Q8TAV3 AK000366 BAA91114 BC025761 AAH25761 XM_011515440 XP_011513742 XM_011515441 XP_011513743 NM_017781 NP_060251
|
| Function |
Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:16551781, PubMed:24278521). Actives also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products (PubMed:20805301). Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids (PubMed:22591743). {ECO:0000269|PubMed:16551781, ECO:0000269|PubMed:20805301, ECO:0000269|PubMed:22591743, ECO:0000269|PubMed:24278521}.
|
| Subcellular Location |
Endoplasmic reticulum lumen {ECO:0000269|PubMed:20805301}. Cell membrane {ECO:0000269|PubMed:20805301}. Note=About 8% are expressed on the cell surface. {ECO:0000269|PubMed:20805301}.
|
| Tissue Specificity |
Very low levels are detected in fetal and adult tissues. Highly expressed in several tumor samples, in particular colon and adrenal tumors. {ECO:0000269|PubMed:16426568}.
|