Gene Symbol |
PLIN1
|
Entrez Gene |
5346
|
Alt Symbol |
FPLD4, PERI, PLIN
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
perilipin 1
|
Other Description |
lipid droplet-associated protein|perilipin-1
|
Swissprots |
Q8N5Y6 O60240
|
Accessions |
EAX02061 O60240 AB005293 BAA25420 AK310907 BC031084 AAH31084 BQ003487 CA427560 CB266260 CB266707 XM_005254934 XP_005254991 NM_001145311 NP_001138783 NM_002666 NP_002657
|
Function |
Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone- sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. {ECO:0000269|PubMed:23399566}.
|
Subcellular Location |
Endoplasmic reticulum {ECO:0000269|PubMed:23399566}. Lipid droplet {ECO:0000269|PubMed:23399566}. Note=Lipid droplet surface- associated.
|
Tissue Specificity |
Adipocytes. {ECO:0000269|PubMed:9521880}.
|
Top Pathways |
PPAR signaling pathway
|