Gene Symbol | PLIN1 |
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Entrez Gene | 5346 |
Alt Symbol | FPLD4, PERI, PLIN |
Species | Human |
Gene Type | protein-coding |
Description | perilipin 1 |
Other Description | lipid droplet-associated protein|perilipin-1 |
Swissprots | Q8N5Y6 O60240 |
Accessions | EAX02061 O60240 AB005293 BAA25420 AK310907 BC031084 AAH31084 BQ003487 CA427560 CB266260 CB266707 XM_005254934 XP_005254991 NM_001145311 NP_001138783 NM_002666 NP_002657 |
Function | Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone- sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. {ECO:0000269|PubMed:23399566}. |
Subcellular Location | Endoplasmic reticulum {ECO:0000269|PubMed:23399566}. Lipid droplet {ECO:0000269|PubMed:23399566}. Note=Lipid droplet surface- associated. |
Tissue Specificity | Adipocytes. {ECO:0000269|PubMed:9521880}. |
Top Pathways | PPAR signaling pathway |
Perilipin CRISPR/Cas9 KO Plasmid (h) - sc-401305 from Santa Cruz Biotechnology
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Perilipin HDR Plasmid (h) - sc-401305-HDR from Santa Cruz Biotechnology
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Perilipin Double Nickase Plasmid (h) - sc-401305-NIC from Santa Cruz Biotechnology
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Perilipin Double Nickase Plasmid (h2) - sc-401305-NIC-2 from Santa Cruz Biotechnology
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Perilipin CRISPR Activation Plasmid (h) - sc-401305-ACT from Santa Cruz Biotechnology
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Perilipin CRISPR Activation Plasmid (h2) - sc-401305-ACT-2 from Santa Cruz Biotechnology
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Perilipin Lentiviral Activation Particles (h) - sc-401305-LAC from Santa Cruz Biotechnology
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Perilipin Lentiviral Activation Particles (h2) - sc-401305-LAC-2 from Santa Cruz Biotechnology
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Perilipin siRNA (h) - sc-61322 from Santa Cruz Biotechnology
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Perilipin shRNA Plasmid (h) - sc-61322-SH from Santa Cruz Biotechnology
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Perilipin shRNA (h) Lentiviral Particles - sc-61322-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN16982 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16982 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08885 from Sigma-Aldrich
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PLIN1 siRNA (Human) - CRH3585 from Cohesion Biosciences
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Perilipin CRISPR/Cas9 KO Plasmid (h2) - sc-401305-KO-2 from Santa Cruz Biotechnology
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Perilipin HDR Plasmid (h2) - sc-401305-HDR-2 from Santa Cruz Biotechnology
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Human PLIN1 siRNA - orb264087 from Biorbyt
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PLIN1 shRNA Plasmid (Human) - CHH3585 from Cohesion Biosciences
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PLIN1 miRNA 3'UTR clone - MiUTR3H-01692 from Creative biogene
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PLIN1 miRNA 3'UTR clone - MiUTR3H-01693 from Creative biogene
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