KLF1

Gene Symbol	KLF1
Entrez Gene	10661
Alt Symbol	CDAN4, EKLF, HBFQTL6, INLU
Species	Human
Gene Type	protein-coding
Description	Kruppel-like factor 1 (erythroid)
Other Description	Krueppel-like factor 1|erythroid Kruppel-like factor|erythroid krueppel-like transcription factor|erythroid-specific transcription factor EKLF|monoclonal antibody A3D8
Swissprots	Q13351 Q6PIJ5 Q92899
Accessions	AAB51173 AAC50562 ACJ26762 ACJ26763 ACM18112 ACM18113 ACM18114 ACM18115 ACM18116 AFW90650 AHA61453 AHA61454 EAW84323 Q13351 BC033580 AAH33580 BC040000 U65404 AAC51108 XM_011527642 XP_011525944 NM_006563 NP_006554
Function	Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:21055716}. Note=Colocalizes with SUMO1 in nuclear speckles. {ECO:0000250}.
Tissue Specificity	Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines. {ECO:0000269|PubMed:8924208, ECO:0000269|PubMed:9119377}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EKLF (V-17) - sc-27192 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

EKLF (H-210) - sc-14034 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

EKLF (C-12) - sc-27193 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-EKLF / KLF1 antibody - ab88417 from Abcam Prices $378.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-EKLF / KLF1 antibody - ab49158 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EKLF / KLF1 antibody - ab56862 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-EKLF / KLF1 antibody - ab90680 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EKLF / KLF1 antibody - ab188039 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EKLF / KLF1 antibody [1B6A3] - ab175372 from Abcam Prices $384.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1B6A3

Anti-EKLF / KLF1 antibody - ChIP Grade - ab2483 from Abcam Prices $382.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-EKLF / KLF1 Antibody (aa208-362, clone 1B6A3) - LS-C191841 from LifeSpan Bioscience Prices $365.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1B6A3

Anti-EKLF / KLF1 Antibody (C-Terminus) - LS-C46845 from LifeSpan Bioscience Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-EKLF / KLF1 Antibody (aa2-15) - LS-C55033 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-EKLF / KLF1 Antibody (aa188-237) - LS-C30873 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-EKLF / KLF1 Antibody (aa248-276, AP) - LS-C215454 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EKLF / KLF1 Antibody (aa248-276, APC) - LS-C215455 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EKLF / KLF1 Antibody (aa248-276, FITC) - LS-C215457 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EKLF / KLF1 Antibody (aa248-276, Biotin) - LS-C215456 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EKLF / KLF1 Antibody (aa248-276, Azide-free, HRP) - LS-C215458 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EKLF / KLF1 Antibody (aa248-276, PE) - LS-C215459 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EKLF / KLF1 Antibody (aa183-237) - LS-C308651 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-EKLF / KLF1 Antibody (aa247-276) - LS-C322499 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EKLF / KLF1 Antibody (aa161-210) - LS-C79967 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-EKLF / KLF1 Antibody (Trp318) - LS-C176929 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-EKLF / KLF1 Antibody (N-Terminus) - LS-C109716 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Search more