KLF1

Gene Symbol	KLF1
Entrez Gene	10661
Alt Symbol	CDAN4, EKLF, HBFQTL6, INLU
Species	Human
Gene Type	protein-coding
Description	Kruppel-like factor 1 (erythroid)
Other Description	Krueppel-like factor 1|erythroid Kruppel-like factor|erythroid krueppel-like transcription factor|erythroid-specific transcription factor EKLF|monoclonal antibody A3D8
Swissprots	Q13351 Q6PIJ5 Q92899
Accessions	AAB51173 AAC50562 ACJ26762 ACJ26763 ACM18112 ACM18113 ACM18114 ACM18115 ACM18116 AFW90650 AHA61453 AHA61454 EAW84323 Q13351 BC033580 AAH33580 BC040000 U65404 AAC51108 XM_011527642 XP_011525944 NM_006563 NP_006554
Function	Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:21055716}. Note=Colocalizes with SUMO1 in nuclear speckles. {ECO:0000250}.
Tissue Specificity	Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines. {ECO:0000269|PubMed:8924208, ECO:0000269|PubMed:9119377}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EKLF / KLF1 peptide - ab45462 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human EKLF / KLF1 full length protein - ab131863 from Abcam Category Protein Source Wheat germ Species Human

Human EKLF / KLF1 peptide - ab39330 from Abcam Category Peptide

Human EKLF / KLF1 protein fragment - ab161099 from Abcam Category Protein Source Wheat germ Species Human

EKLF / KLF1 Antibody Blocking Peptide - LS-E3327 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EKLF / KLF1 Antibody Blocking Peptide - LS-E25338 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EKLF / KLF1 Antibody Blocking Peptide - LS-E11549 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EKLF / KLF1 Antibody Blocking Peptide - LS-E11009 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human KLF1 Protein - H00010661-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human KLF1 Protein - H00010661-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

KLF1-Antibody-C-term-Blocking-Peptide - BP14499b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

KLF1 blocking peptide - GTX89710-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Pig, Bovine

KLF1/5/7 Peptide - orb224355 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Zebrafish

EKLF / KLF1 Peptide - AC21-0166-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Krueppel-like factor 1 (KLF1) - H00010661-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Krueppel-like factor 1 (KLF1) - H00010661-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Krueppel-like factor 1 (KLF1) - H00010661-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Krueppel-like factor 1 (KLF1) - H00010661-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

KLF1 Peptide - 45-801P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

KLF1 fusion protein - Ag13467 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

KLF1 fusion protein - Ag13469 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human KLF1, GST-tagged - KLF1-394H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Kruppel Like Factor 1, Erythroid (KLF1) - RPD368Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Kruppel Like Factor 1, Erythroid (KLF1) - RPD368Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

KLF1/5/7 Blocking Peptide - CBP3469 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Zebrafish

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