| Gene Symbol |
KLF1
|
| Entrez Gene |
10661
|
| Alt Symbol |
CDAN4, EKLF, HBFQTL6, INLU
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Kruppel-like factor 1 (erythroid)
|
| Other Description |
Krueppel-like factor 1|erythroid Kruppel-like factor|erythroid krueppel-like transcription factor|erythroid-specific transcription factor EKLF|monoclonal antibody A3D8
|
| Swissprots |
Q13351 Q6PIJ5 Q92899
|
| Accessions |
AAB51173 AAC50562 ACJ26762 ACJ26763 ACM18112 ACM18113 ACM18114 ACM18115 ACM18116 AFW90650 AHA61453 AHA61454 EAW84323 Q13351 BC033580 AAH33580 BC040000 U65404 AAC51108 XM_011527642 XP_011525944 NM_006563 NP_006554
|
| Function |
Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:21055716}. Note=Colocalizes with SUMO1 in nuclear speckles. {ECO:0000250}.
|
| Tissue Specificity |
Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines. {ECO:0000269|PubMed:8924208, ECO:0000269|PubMed:9119377}.
|