| Gene Symbol |
DSC2
|
| Entrez Gene |
1824
|
| Alt Symbol |
ARVD11, CDHF2, DG2, DGII/III, DSC3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
desmocollin 2
|
| Other Description |
cadherin family member 2|desmocollin-2|desmosomal glycoprotein II/III
|
| Swissprots |
Q02487
|
| Accessions |
ABM88172 CAL91822 CAL91823 EAX01250 EAX01251 Q02487 AK290313 BAF83002 AK297029 BAG59557 BC063291 AAH63291 BE350090 BE813598 BU735677 BX648425 CAH56152 CR749226 CAH18082 DC382631 EF017811 ABM88170 EF017812 ABM88171 X56807 CAA40141 XM_005258206 XP_005258263 NM_004949 NP_004940 NM_024422 NP_077740
|
| Function |
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:21062920}; Single-pass type I membrane protein {ECO:0000269|PubMed:21062920}. Cell junction, desmosome {ECO:0000269|PubMed:21062920}.
|
| Tissue Specificity |
Expressed in epithelia, myocardium and lymph nodes.
|
| Top Pathways |
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
|
![Western Blot: Desmocollin 2 Overexpression Lysate (Adult Normal) [NBP2-10513] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Desmocollin 2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1082_Desmocollin%25202%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10513-img0001.jpg)