| Gene Symbol | EPPIN |
|---|---|
| Entrez Gene | 57119 |
| Alt Symbol | CT71, CT72, SPINLW1, WAP7, WFDC7, dJ461P17.2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | epididymal peptidase inhibitor |
| Other Description | WAP four-disulfide core domain protein 7|cancer/testis antigen 71|cancer/testis antigen 72|epididymal protease inhibitor|eppin|protease inhibitor WAP7|serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin) |
| Swissprots | Q86TP9 Q9HD30 A6PVD6 Q96SD7 O95925 |
| Accessions | CAB37635 EAW75831 EAW75832 O95925 AF286368 AAG00546 AF286369 AAG00547 AF286370 AAG00548 AK126022 BAG54278 AK311906 BAG34847 AL118493 CAB56343 BC003675 AAH03675 BC044829 AAH44829 BC053369 AAH53369 BF057305 DA821702 DC395362 HQ448506 ADQ32986 NM_001302861 NP_001289790 NM_020398 NP_065131 NM_181502 |
| Function | Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility. {ECO:0000269|PubMed:15229136, ECO:0000269|PubMed:17644992}. |
| Subcellular Location | Isoform 1: Secreted. Cell surface. Note=Bound to the surface of testicular and on the head and tail of ejaculate spermatozoa. |
| Tissue Specificity | In testis, expressed and secreted by Sertoli cells, appearing on the surface of testicular and ejaculate spermatozoa. Expressed in the spermatogonia and the earliest preleptotene spermatocytes. In the epididymis, is expressed and secreted by epithelial cells and covers the surface of epididymal spermatozoa and ciliated epithelial cells (at protein level). Expressed specifically in epididymis and testis. Isoform 2 is expressed only in the epididymis. Weak expression is detected in myoid cells as well as spermatogenic cells. {ECO:0000269|PubMed:11404006, ECO:0000269|PubMed:21461566}. |