EPPIN
| Gene Symbol | EPPIN |
|---|---|
| Entrez Gene | 57119 |
| Alt Symbol | CT71, CT72, SPINLW1, WAP7, WFDC7, dJ461P17.2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | epididymal peptidase inhibitor |
| Other Description | WAP four-disulfide core domain protein 7|cancer/testis antigen 71|cancer/testis antigen 72|epididymal protease inhibitor|eppin|protease inhibitor WAP7|serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin) |
| Swissprots | Q86TP9 Q9HD30 A6PVD6 Q96SD7 O95925 |
| Accessions | CAB37635 EAW75831 EAW75832 O95925 AF286368 AAG00546 AF286369 AAG00547 AF286370 AAG00548 AK126022 BAG54278 AK311906 BAG34847 AL118493 CAB56343 BC003675 AAH03675 BC044829 AAH44829 BC053369 AAH53369 BF057305 DA821702 DC395362 HQ448506 ADQ32986 NM_001302861 NP_001289790 NM_020398 NP_065131 NM_181502 |
| Function | Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility. {ECO:0000269|PubMed:15229136, ECO:0000269|PubMed:17644992}. |
| Subcellular Location | Isoform 1: Secreted. Cell surface. Note=Bound to the surface of testicular and on the head and tail of ejaculate spermatozoa. |
| Tissue Specificity | In testis, expressed and secreted by Sertoli cells, appearing on the surface of testicular and ejaculate spermatozoa. Expressed in the spermatogonia and the earliest preleptotene spermatocytes. In the epididymis, is expressed and secreted by epithelial cells and covers the surface of epididymal spermatozoa and ciliated epithelial cells (at protein level). Expressed specifically in epididymis and testis. Isoform 2 is expressed only in the epididymis. Weak expression is detected in myoid cells as well as spermatogenic cells. {ECO:0000269|PubMed:11404006, ECO:0000269|PubMed:21461566}. |
Eppin CRISPR/Cas9 KO Plasmid (h) - sc-405234 from Santa Cruz Biotechnology
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Eppin HDR Plasmid (h) - sc-405234-HDR from Santa Cruz Biotechnology
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Eppin Double Nickase Plasmid (h) - sc-405234-NIC from Santa Cruz Biotechnology
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Eppin Double Nickase Plasmid (h2) - sc-405234-NIC-2 from Santa Cruz Biotechnology
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Eppin CRISPR Activation Plasmid (h) - sc-405234-ACT from Santa Cruz Biotechnology
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Eppin CRISPR Activation Plasmid (h2) - sc-405234-ACT-2 from Santa Cruz Biotechnology
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Eppin Lentiviral Activation Particles (h) - sc-405234-LAC from Santa Cruz Biotechnology
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Eppin Lentiviral Activation Particles (h2) - sc-405234-LAC-2 from Santa Cruz Biotechnology
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Eppin siRNA (h) - sc-44415 from Santa Cruz Biotechnology
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Eppin shRNA Plasmid (h) - sc-44415-SH from Santa Cruz Biotechnology
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Eppin shRNA (h) Lentiviral Particles - sc-44415-V from Santa Cruz Biotechnology
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SPINLW1 RNAi - H00057119-R01 from Novus Biologicals
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MISSION® esiRNA - EHU052681 from Sigma-Aldrich
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MISSION® esiRNA - EHU061491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20488 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20488 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09715 from Sigma-Aldrich
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EPPIN siRNA (Human) - CRJ1335 from Cohesion Biosciences
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SPINLW1 RNAi - H00057119-R02 from Novus Biologicals
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Human EPPIN siRNA - orb271836 from Biorbyt
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EPPIN shRNA Plasmid (Human) - CHJ1335 from Cohesion Biosciences
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