EPPIN

Gene Symbol EPPIN
Entrez Gene 57119
Alt Symbol CT71, CT72, SPINLW1, WAP7, WFDC7, dJ461P17.2
Species Human
Gene Type protein-coding
Description epididymal peptidase inhibitor
Other Description WAP four-disulfide core domain protein 7|cancer/testis antigen 71|cancer/testis antigen 72|epididymal protease inhibitor|eppin|protease inhibitor WAP7|serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin)
Swissprots Q86TP9 Q9HD30 A6PVD6 Q96SD7 O95925
Accessions CAB37635 EAW75831 EAW75832 O95925 AF286368 AAG00546 AF286369 AAG00547 AF286370 AAG00548 AK126022 BAG54278 AK311906 BAG34847 AL118493 CAB56343 BC003675 AAH03675 BC044829 AAH44829 BC053369 AAH53369 BF057305 DA821702 DC395362 HQ448506 ADQ32986 NM_001302861 NP_001289790 NM_020398 NP_065131 NM_181502
Function Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility. {ECO:0000269|PubMed:15229136, ECO:0000269|PubMed:17644992}.
Subcellular Location Isoform 1: Secreted. Cell surface. Note=Bound to the surface of testicular and on the head and tail of ejaculate spermatozoa.
Tissue Specificity In testis, expressed and secreted by Sertoli cells, appearing on the surface of testicular and ejaculate spermatozoa. Expressed in the spermatogonia and the earliest preleptotene spermatocytes. In the epididymis, is expressed and secreted by epithelial cells and covers the surface of epididymal spermatozoa and ciliated epithelial cells (at protein level). Expressed specifically in epididymis and testis. Isoform 2 is expressed only in the epididymis. Weak expression is detected in myoid cells as well as spermatogenic cells. {ECO:0000269|PubMed:11404006, ECO:0000269|PubMed:21461566}.

Human SPINLW1 full length protein - ab163490 from Abcam

Category Protein
Source Wheat germ
Species Human
ab163490 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human SPINLW1 protein fragment - ab163491 from Abcam

Category Protein
Source Wheat germ
Species Human
ab163491 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Recombinant Human SPINLW1 Protein - H00057119-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Recombinant Human SPINLW1 Protein - H00057119-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Eppin / SPINLW1 - H00057119-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

Eppin / SPINLW1 - H00057119-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

Eppin / SPINLW1 - H00057119-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

Eppin / SPINLW1 - H00057119-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

SPINLW1 fusion protein - Ag6365 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

SPINLW1 fusion protein - ag5757 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human EPPIN - EPPIN-918H from Creative Biomart

Category Protein
Source Mammalian Cells
Species Human

Recombinant Human EPPIN-WFDC6 - EPPIN-WFDC6-1769H from Creative Biomart

Category Protein
Source Mammalian Cells
Species Human

Recombinant Human SPINLW1, His-tagged - SPINLW1-2920H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Eppin(SPINLW1) - CSB-YP022583HU CSB-EP022583HU CSB-BP022583HU CSB-MP022583HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

EPPIN Peptide, Human - M34GP05008H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Eppin (SPINLW1), Recombinant Protein - MBS1077237 from MyBioSource

Category Protein
Prices $845.00, $845.00, $1,070.00, $1,070.00, $1,220.00, $1,220.00, $1,675.00, $1,675.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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