| Gene Symbol |
ACADSB
|
| Entrez Gene |
36
|
| Alt Symbol |
2-MEBCAD, ACAD7, SBCAD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
acyl-CoA dehydrogenase, short/branched chain
|
| Other Description |
2-methyl branched chain acyl-CoA dehydrogenase|2-methylbutyryl-coenzyme A dehydrogenase|acyl-Coenzyme A dehydrogenase, short/branched chain|short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
|
| Swissprots |
Q5SQN6 P45954 Q96CX7 B4DQ51
|
| Accessions |
AAF97921 EAW49291 P45954 AK298638 BAG60813 AK314241 BAG36909 AL831821 CAD38535 BC013756 AAH13756 BC020931 BC032395 BC045723 BE875638 DA964130 HQ447278 ADQ31765 U12778 AAA74424 NM_001609 NP_001600
|
| Function |
Has greatest activity toward short branched chain acyl- CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl- CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent.
|
| Subcellular Location |
Mitochondrion matrix.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Fatty acid degradation, Valine, leucine and isoleucine degradation, Fatty acid metabolism
|
![Western Blot: ACADSB Overexpression Lysate (Adult Normal) [NBL1-07222] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ACADSB.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4550_ACADSB%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-07222-img0002.jpg)