Gene Symbol | ACADSB |
---|---|
Entrez Gene | 36 |
Alt Symbol | 2-MEBCAD, ACAD7, SBCAD |
Species | Human |
Gene Type | protein-coding |
Description | acyl-CoA dehydrogenase, short/branched chain |
Other Description | 2-methyl branched chain acyl-CoA dehydrogenase|2-methylbutyryl-coenzyme A dehydrogenase|acyl-Coenzyme A dehydrogenase, short/branched chain|short/branched chain specific acyl-CoA dehydrogenase, mitochondrial |
Swissprots | Q5SQN6 P45954 Q96CX7 B4DQ51 |
Accessions | AAF97921 EAW49291 P45954 AK298638 BAG60813 AK314241 BAG36909 AL831821 CAD38535 BC013756 AAH13756 BC020931 BC032395 BC045723 BE875638 DA964130 HQ447278 ADQ31765 U12778 AAA74424 NM_001609 NP_001600 |
Function | Has greatest activity toward short branched chain acyl- CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl- CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent. |
Subcellular Location | Mitochondrion matrix. |
Tissue Specificity | Ubiquitous. |
Top Pathways | Fatty acid degradation, Valine, leucine and isoleucine degradation, Fatty acid metabolism |